严重运动障碍和智力障碍患者的血清 25(OH)D 和维生素 K1 水平:日本单中心经验。

IF 1.4 4区 医学 Q4 CLINICAL NEUROLOGY
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引用次数: 0

摘要

目的:调查严重运动和智力障碍(SMID)患者是否存在营养性维生素 D 和 K 不足的问题,并明确所需的维生素补充剂:这项前瞻性观察研究招募了接受机构护理的日本成年重度运动与智力障碍(SMID)患者,这些患者在 2020 年 2 月至 2022 年 2 月期间接受年度体检时接受了血液采样。测量血清维生素 K1 和 25- 羟基维生素 D(25(OH)D)水平,以确定它们与血清非羧化骨钙素(ucOC)水平的关系。使用相应的血清水平比较了管饲和口服维生素 D 和 K 摄入量的 SMID 患者和对照组参与者:研究包括 124 名 SMID 患者(56 名男性和 68 名女性;平均年龄:53.0 岁)和 20 名对照组参与者。SMID组的血清25(OH)D水平明显高于对照组,口服SMID组的血清25(OH)D水平明显高于管饲SMID组。在管饲SMID组中,维生素D摄入量低于每日推荐摄入量,且与血清25(OH)D水平相关。管饲组的维生素 K 每日摄入量低于建议摄入量,但与血清维生素 K 水平无关。SMID组的血清ucOC水平明显高于对照组。管饲与血清 25(OH)D 水平呈明显正相关。血清25(OH)D水平与血清维生素K1水平无关:SMID组的ucOC水平高于对照组,这可能是由于日常维生素K和D缺乏所致。建议补充维生素D以降低ucOC水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum 25(OH)D and vitamin K1 levels in patients with severe motor and intellectual disability: A Japanese single-center experience

Purpose

To investigate whether patients with severe motor and intellectual disability (SMID) have nutritional vitamin D and K insufficiencies and clarify the required vitamin supplementation.

Methods

This prospective observational study enrolled Japanese adults with SMID receiving institutionalized care who underwent blood sampling between February 2020 and February 2022 during annual medical checkups. Serum vitamin K1 and 25-hydroxy vitamin D (25(OH)D) levels were measured to determine their relationship with serum uncarboxylated osteocalcin (ucOC) levels. Vitamin D and K intake was compared among tube-fed and oral-intake patients with SMID and control participants using corresponding serum levels.

Results

The study included 124 patients with SMID (56 men and 68 women; mean age: 53.0 years) and 20 control participants. Serum 25(OH)D levels were significantly higher in the SMID group than in the control group and the oral intake SMID group than in the tube-fed SMID group. In the tube-fed SMID group, vitamin D intake was lower than the daily recommended intake and correlated with serum 25(OH)D levels. Daily vitamin K intake in the tube-fed group was lower than recommended but not correlated with serum vitamin K levels. Serum ucOC levels were significantly higher in the SMID group than in the control group. Tube feeding was significantly and positively correlated with serum 25(OH)D levels. Serum 25(OH)D levels were not correlated with serum vitamin K1 levels.

Conclusions

The SMID group had higher ucOC levels than the control group, possibly owing to daily vitamin K and D deficiencies. Vitamin D supplementation is recommended to decrease ucOC levels.

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来源期刊
Brain & Development
Brain & Development 医学-临床神经学
CiteScore
3.60
自引率
0.00%
发文量
153
审稿时长
50 days
期刊介绍: Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.
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