纳米 siRNA 递送系统通过调节晶状体上皮细胞凋亡防治老年性白内障的应用价值

IF 0.7 4区材料科学 Q3 Materials Science

Materials Express Pub Date : 2024-06-01 DOI:10.1166/mex.2024.2677

Xiaoqing Wei, Xiaoxing Wang, Ping Wang

{"title":"纳米 siRNA 递送系统通过调节晶状体上皮细胞凋亡防治老年性白内障的应用价值","authors":"Xiaoqing Wei, Xiaoxing Wang, Ping Wang","doi":"10.1166/mex.2024.2677","DOIUrl":null,"url":null,"abstract":"In this study, a novel nano-siRNA delivery system loaded with anti-ESR1 siRNA was designed. In a biological study, the new system was evaluated for the treatment and care of senile cataracts. The system significantly upregulated the expression level of the anti-apoptotic protein BCL-2,\n while significantly inhibiting the expression level of the inhibitory apoptotic protein BAX, thereby regulating apoptosis in lens epithelial cells. The system can be developed as a drug for the treatment of senile cataracts.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application value of a nano-siRNA delivery system in treatment against senile cataracts by modulating apoptosis in lens epithelial cells\",\"authors\":\"Xiaoqing Wei, Xiaoxing Wang, Ping Wang\",\"doi\":\"10.1166/mex.2024.2677\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, a novel nano-siRNA delivery system loaded with anti-ESR1 siRNA was designed. In a biological study, the new system was evaluated for the treatment and care of senile cataracts. The system significantly upregulated the expression level of the anti-apoptotic protein BCL-2,\\n while significantly inhibiting the expression level of the inhibitory apoptotic protein BAX, thereby regulating apoptosis in lens epithelial cells. The system can be developed as a drug for the treatment of senile cataracts.\",\"PeriodicalId\":18318,\"journal\":{\"name\":\"Materials Express\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Express\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1166/mex.2024.2677\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Materials Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Express","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1166/mex.2024.2677","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Materials Science","Score":null,"Total":0}

引用次数: 0

摘要

本研究设计了一种新型纳米 siRNA 递送系统，其中装载了抗 ESR1 siRNA。在一项生物学研究中，对该新系统治疗和护理老年性白内障的效果进行了评估。该系统能明显提高抗凋亡蛋白 BCL-2 的表达水平，同时明显抑制抑制性凋亡蛋白 BAX 的表达水平，从而调节晶状体上皮细胞的凋亡。该系统可开发为治疗老年性白内障的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Application value of a nano-siRNA delivery system in treatment against senile cataracts by modulating apoptosis in lens epithelial cells

In this study, a novel nano-siRNA delivery system loaded with anti-ESR1 siRNA was designed. In a biological study, the new system was evaluated for the treatment and care of senile cataracts. The system significantly upregulated the expression level of the anti-apoptotic protein BCL-2, while significantly inhibiting the expression level of the inhibitory apoptotic protein BAX, thereby regulating apoptosis in lens epithelial cells. The system can be developed as a drug for the treatment of senile cataracts.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Information not localized