细胞神经生理学中的网络图案。

IF 14.6 1区 医学 Q1 NEUROSCIENCES
Trends in Neurosciences Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI:10.1016/j.tins.2024.04.008
Divyansh Mittal, Rishikesh Narayanan
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引用次数: 0

摘要

网络科学和图论的概念,包括网络主题框架,经常被用于研究神经元网络和其他生物复杂系统。基于网络的方法也可用于研究单个神经元的功能,在这种方法中,离子通道和膜电压等细胞元素被概念化为网络中的节点,它们之间的相互作用用边表示。在这种情况下,网络图案提供了功能构件,有助于阐明细胞神经生理学的原理。在这篇综述中,我们论证了在神经元内运行的网络主题为定义单神经元生理学和神经元适应性的功能结构提供了工具。我们强调了这种计算模式在动作电位产生、神经元振荡、树突整合和神经元可塑性的细胞机制中的存在。未来应用网络图案视角的工作可能有助于破译神经元的功能复杂性及其在健康和疾病期间的适应性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Network motifs in cellular neurophysiology.

Concepts from network science and graph theory, including the framework of network motifs, have been frequently applied in studying neuronal networks and other biological complex systems. Network-based approaches can also be used to study the functions of individual neurons, where cellular elements such as ion channels and membrane voltage are conceptualized as nodes within a network, and their interactions are denoted by edges. Network motifs in this context provide functional building blocks that help to illuminate the principles of cellular neurophysiology. In this review we build a case that network motifs operating within neurons provide tools for defining the functional architecture of single-neuron physiology and neuronal adaptations. We highlight the presence of such computational motifs in the cellular mechanisms underlying action potential generation, neuronal oscillations, dendritic integration, and neuronal plasticity. Future work applying the network motifs perspective may help to decipher the functional complexities of neurons and their adaptation during health and disease.

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来源期刊
Trends in Neurosciences
Trends in Neurosciences 医学-神经科学
CiteScore
26.50
自引率
1.30%
发文量
123
审稿时长
6-12 weeks
期刊介绍: For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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