益生菌对不同人群早产儿肠道微生物群的影响:系统回顾与元分析

IF 8 1区 医学 Q1 NUTRITION & DIETETICS
Pandi He , Leilei Yu , Fengwei Tian , Wei Chen , Hao Zhang , Qixiao Zhai
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引用次数: 0

摘要

生命早期的微生物群与婴儿尤其是早产儿的健康密切相关。益生菌是早产儿肠道微生物群发展的重要推动力;然而,对于接受益生菌治疗的早产儿特定微生物群的特征,目前还没有达成共识。在本研究中,我们对 5 个微生物组数据集(来自 706 名早产儿的 1816 份粪便样本)进行了荟萃分析,以比较不同人群中接触益生菌的早产儿与未接触益生菌的早产儿的肠道微生物群。尽管具体研究存在差异,但我们发现在不同队列的早产儿中,对照组和益生菌组的肠道微生物组成和预测功能途径存在一致的差异。添加了益生菌的早产儿肠道微生物群中最一致的变化是不动杆菌属、双歧杆菌属和乳酸杆菌属的富集以及潜在致病菌芬格氏菌属、维氏菌属和克雷伯氏菌属的减少。益生菌促使微生物群转变为多种早产儿肠道群落类型,值得注意的是,早产儿肠道群落类型 3 的α-多样性最高,富含双歧杆菌和乳杆菌属。 在功能层面,早产儿补充益生菌后,参与肽聚糖生物合成的主要预测微生物通路持续增加;相比之下,与血红素生物合成相关的关键通路持续减少。有趣的是,在使用混合益生菌的早产儿肠道微生物群中,双歧杆菌逐渐占据主导地位,而不是乳酸杆菌,尽管两种益生菌株的用量相同。综上所述,我们的荟萃分析表明,益生菌有助于在细菌群落的分类和功能层面重塑早产儿的微生物生态系统。更多标准化的相关研究可能有助于更好地理解益生菌、肠道微生物群和后续疾病风险之间的相互关系,从而有助于为早产儿提供及时的营养喂养指导。本系统综述和荟萃分析已在 PROSPERO (https://www.crd.york.ac.uk/PROSPERO/) 上注册,注册号为 CRD42023447901。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Probiotics on Preterm Infant Gut Microbiota Across Populations: A Systematic Review and Meta-Analysis

Microbiota in early life is closely associated with the health of infants, especially premature ones. Probiotics are important drivers of gut microbiota development in preterm infants; however, there is no consensus regarding the characteristics of specific microbiota in preterm infants receiving probiotics. In this study, we performed a meta-analysis of 5 microbiome data sets (1816 stool samples from 706 preterm infants) to compare the gut microbiota of preterm infants exposed to probiotics with that of preterm infants not exposed to probiotics across populations. Despite study-specific variations, we found consistent differences in gut microbial composition and predicted functional pathways between the control and probiotic groups across different cohorts of preterm infants. The enrichment of Acinetobacter, Bifidobacterium, and Lactobacillus spp and the depletion of the potentially pathogenic bacteria Finegoldia, Veillonella, and Klebsiella spp. were the most consistent changes in the gut microbiota of preterm infants supplemented with probiotics. Probiotics drove microbiome transition into multiple preterm gut community types, and notably, preterm gut community type 3 had the highest α-diversity, with enrichment of Bifidobacterium and Bacteroides spp. At the functional level, the major predicted microbial pathways involved in peptidoglycan biosynthesis consistently increased in preterm infants supplemented with probiotics; in contrast, the crucial pathways associated with heme biosynthesis consistently decreased. Interestingly, Bifidobacterium sp. rather than Lactobacillus sp. gradually became dominant in gut microbiota of preterm infants using mixed probiotics, although both probiotic strains were administered at the same dosage. Taken together, our meta-analysis suggests that probiotics contribute to reshaping the microbial ecosystem of preterm infants at both the taxonomic and functional levels of the bacterial community. More standardized and relevant studies may contribute to better understanding the crosstalk among probiotics, the gut microbiota, and subsequent disease risk, which could help to give timely nutritional feeding guidance to preterm infants.

This systematic review and meta-analysis was registered at PROSPERO (https://www.crd.york.ac.uk/PROSPERO/) as CRD42023447901.

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来源期刊
Advances in Nutrition
Advances in Nutrition 医学-营养学
CiteScore
17.40
自引率
2.20%
发文量
117
审稿时长
56 days
期刊介绍: Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.
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