膳食脂肪对老年人认知能力和肌肉疏松症的影响。

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Xianyun Wang, Chengyan Qi, Xiaoying Li, Dajun Li, Huini Ding, Jing Shen, Yijia Liu, Yuandi Xi
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引用次数: 0

摘要

背景与目的阐明膳食脂肪对轻度认知障碍和肌肉疏松症之间关系的作用,帮助识别和预防老年人认知和肌肉功能的衰退:这项研究涉及 1812 名 61 至 92 岁的老年人。通过生物电阻抗分析评估了身体成分和基础代谢率。认知功能和饮食营养通过神经心理学评估和食物摄入频率问卷进行评估。脂质组学分析采用超高效液相色谱-Qtrap-MS/MS进行:MCI和SA是相互影响的因素,MUFA、PUFA摄入量较低和脂肪摄入量较高与认知功能障碍和/或SA有关(p < 0.05)。PUFA对MCI合并SA很重要(与Q1相比,Q4 OR:0.176,95%CI:0.058,0.533)。脂质组学分析显示,三酰甘油(TAG)中含有更多饱和双键的碳链可能与认知障碍和 SA 的进展密切相关(P < 0.05)。结论:结论:不饱和脂肪酸摄入不足与认知能力下降和 SA 进展有关。影响肌肉健康的 MUFA、脂肪和 PUFA 对 MCI 合并 SA 的影响更大。减少 MUFA 的摄入量和增加饱和双键脂肪酸的摄入量可能是导致老年人认知障碍和 SA 的关键因素。它们有可能作为前瞻性生物标志物,显示老年人群认知能力下降和/或SA的风险较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of dietary fats on cognition and sarcopenia in the elderly.

Background and objectives: To elucidate the role of dietary fats on the relationship between mild cognitive impairment and sarcopenia and help identifying and preventing the decline of cognitive and muscle function in elderly individuals.

Methods and study design: The study conducted involving a group of 1812 individuals between the ages of 61 and 92. Body composition and BMR were assessed by bioelectrical impedance analysis. Cognitive function and dietary nutrition were evaluated by neuropsychological assessments and questionnaire of food intake frequency. Lipidomics analysis was performed using UHPLC-Qtrap-MS/MS.

Results: MCI and SA are mutual influencing factors, lower intake of MUFA, PUFA and higher intake of fat was associated with cognitive dysfunction and/or SA (p < 0.05). PUFA was important for MCI combined with SA (Compared with Q1, Q4 OR: 0.176, 95%CI: 0.058,0.533). Lipidomics analysis revealed that triacylglycerol (TAG) contain more carbon chains with saturated double bonds may be closely related to cognitive impairment and the progression of SA (p < 0.05). While, DAG with carbon chains of unsaturated double bonds is opposite.

Conclusions: Insufficient intake of unsaturated fatty acids was associated with the development of cognitive decline and the progression of SA. MUFA affecting muscle health, fats and PUFA has a greater impact on MCI combined with SA. Less MUFA intake and increasing saturated double-bonded fatty acid intake might be the key factors on promoting cognitive impairment and SA in the elderly. They have the potential to serve as prospective biomarkers indicating a higher risk of cognitive decline and/or SA in the elderly population.

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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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