饮食营养和新陈代谢在结直肠癌中的作用。

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Jinjun Ye, Xing Bao, Jiufeng Wei, Yuanpeng Zhang, Yu Liu, Le Xin
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引用次数: 0

摘要

结肠直肠癌(CRC)是最常见的恶性肿瘤之一,也是全球癌症相关死亡的主要原因。CRC 的发病是由遗传和环境因素共同作用的结果。越来越多的证据表明,膳食营养的改变可能会调节 CRC 的发病风险,葡萄糖、氨基酸、脂质、维生素、微量元素和益生元等特定营养素对 CRC 的发病风险具有保护作用。肿瘤细胞、肿瘤微环境成分和肠道菌群之间的代谢串扰进一步促进了 CRC 细胞的增殖、侵袭和转移,并导致耐药性。本综述总结了分别通过膳食补充或缺乏葡萄糖、氨基酸、脂类、维生素、微量元素和益生元来预防、发病和治疗 CRC 的研究进展。讨论了不同营养素和膳食串联在肿瘤微环境和新陈代谢中发挥的作用,并启发了营养调节对预防和治疗 CRC 的益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of dietary nutrients and metabolism in colorectal cancer.

Colorectal cancer (CRC) is one of the most common malignancies and the leading causes of cancer related deaths worldwide. The development of CRC is driven by a combination of genetic and environmental factors. There is growing evidence that changes in dietary nutrition may modulate the CRC risk, and protective effects on the risk of developing CRC have been advocated for specific nutrients such as glucose, amino acids, lipid, vitamins, micronutrients and prebiotics. Metabolic crosstalk between tumor cells, tumor microenvironment components and intestinal flora further promote proliferation, invasion and metastasis of CRC cells and leads to treatment resistance. This review summarizes the research progress on CRC prevention, pathogenesis, and treatment by dietary supplementation or deficiency of glucose, amino acids, lipids, vitamins, micronutri-ents, and prebiotics, respectively. The roles played by different nutrients and dietary crosstalk in the tumor microenvironment and metabolism are discussed, and nutritional modulation is inspired to be beneficial in the prevention and treatment of CRC.

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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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