通过诱导听力开始前耳蜗内的自发活动,启动中央声音处理电路。

IF 14.6 1区 医学 Q1 NEUROSCIENCES
Trends in Neurosciences Pub Date : 2024-07-01 Epub Date: 2024-05-22 DOI:10.1016/j.tins.2024.04.007
Calvin J Kersbergen, Dwight E Bergles
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引用次数: 0

摘要

感觉系统在完成成熟和感觉传导之前,会经历一段内在产生的神经活动期。在此,我们回顾了描述听觉系统中这种 "自发 "活动的机制和功能的证据。体外和体内研究均表明,这种相关活动是由发育中耳蜗内的非感觉支持细胞启动的,它们会诱发感觉上皮中附近毛细胞群的去极化和猝发发射,这种活动会传递给听觉神经元,这些神经元随后会处理类似的声音特征。这种刻板的神经突发性发射促进了细胞的成熟、突触的完善、对声音的敏感性以及大脑中声音反应域的建立。虽然发育中的听觉系统对干扰很敏感,但它表现出非凡的平衡机制,能保持聋小鼠的周期性突发性发射。在耳聋的情况下保留这种早期自发活动可能会提高后期干预恢复听力的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset.

Sensory systems experience a period of intrinsically generated neural activity before maturation is complete and sensory transduction occurs. Here we review evidence describing the mechanisms and functions of this 'spontaneous' activity in the auditory system. Both ex vivo and in vivo studies indicate that this correlated activity is initiated by non-sensory supporting cells within the developing cochlea, which induce depolarization and burst firing of groups of nearby hair cells in the sensory epithelium, activity that is conveyed to auditory neurons that will later process similar sound features. This stereotyped neural burst firing promotes cellular maturation, synaptic refinement, acoustic sensitivity, and establishment of sound-responsive domains in the brain. While sensitive to perturbation, the developing auditory system exhibits remarkable homeostatic mechanisms to preserve periodic burst firing in deaf mice. Preservation of this early spontaneous activity in the context of deafness may enhance the efficacy of later interventions to restore hearing.

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来源期刊
Trends in Neurosciences
Trends in Neurosciences 医学-神经科学
CiteScore
26.50
自引率
1.30%
发文量
123
审稿时长
6-12 weeks
期刊介绍: For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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