Yi Liu , Jingjing Guo , Hao Cheng , Juan Wang , Yanfeng Tan , Jingjing Zhang , Hongxun Tao , Hongyan Liu , Jianbo Xiao , Dashi Qi , Xinyu Mei
{"title":"蛋氨酸限制饮食:揭示生物机制,增强大脑健康","authors":"Yi Liu , Jingjing Guo , Hao Cheng , Juan Wang , Yanfeng Tan , Jingjing Zhang , Hongxun Tao , Hongyan Liu , Jianbo Xiao , Dashi Qi , Xinyu Mei","doi":"10.1016/j.tifs.2024.104532","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Methionine (Met) uptake and metabolism are integral to various cellular functions. Excessive intake of Met from human diets can lead to numerous health issues. Conversely, methionine restriction (MR) diets have recently gained considerable attention due to their diverse bioactivities. These include anti-cancer, anti-aging and anti-inflammatory, anti-obesity, cardiovascular protection, intestinal improvement, liver protection, brain health improvement, and other effects. The effectiveness of MR in exerting these bioactivities is closely linked to the modulation of critical molecular targets.</p></div><div><h3>Scope and Approach</h3><p>This review offers a thorough and current examination of Met food sources, Met metabolism, the beneficial functions, particularly in brain health, and potential adverse effects of MR diets, along with their underlying molecular mechanisms. Specifically, the impact of MR diets on homocysteine (Hcy) metabolism.</p></div><div><h3>Key Findings and Conclusions</h3><p>In addition to plant-based and animal-based foods, Met can also be obtained from microbe-based foods. MR may be more easily adopted by humans without the need to restrict energy intake. MR offers multiple health benefits, including anti-obesity, anti-diabetic, anti-cancer, cardiovascular protective, and neuroprotective effects. These benefits stem from its impact on various regulatory mechanisms, such as one-carbon metabolism, oxidative stress, mTOR signaling, IGF-I signaling, FGF21 and H<sub>2</sub>S production, epigenetics, and regulation of short-chain fatty acids (SCFAs). N-Hcy-protein is associated with various Hcy pathologies, and MR may effectively block its formation. Clinical trials have demonstrated the efficacy of MR in treating obesity and cancer, highlighting the need for further exploration of its therapeutic potential. Overall, MR diets show promise for the preventing of certain chronic human diseases.</p></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":null,"pages":null},"PeriodicalIF":15.1000,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Methionine Restriction Diets: Unravelling Biological Mechanisms and Enhancing Brain Health\",\"authors\":\"Yi Liu , Jingjing Guo , Hao Cheng , Juan Wang , Yanfeng Tan , Jingjing Zhang , Hongxun Tao , Hongyan Liu , Jianbo Xiao , Dashi Qi , Xinyu Mei\",\"doi\":\"10.1016/j.tifs.2024.104532\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Methionine (Met) uptake and metabolism are integral to various cellular functions. Excessive intake of Met from human diets can lead to numerous health issues. Conversely, methionine restriction (MR) diets have recently gained considerable attention due to their diverse bioactivities. These include anti-cancer, anti-aging and anti-inflammatory, anti-obesity, cardiovascular protection, intestinal improvement, liver protection, brain health improvement, and other effects. The effectiveness of MR in exerting these bioactivities is closely linked to the modulation of critical molecular targets.</p></div><div><h3>Scope and Approach</h3><p>This review offers a thorough and current examination of Met food sources, Met metabolism, the beneficial functions, particularly in brain health, and potential adverse effects of MR diets, along with their underlying molecular mechanisms. Specifically, the impact of MR diets on homocysteine (Hcy) metabolism.</p></div><div><h3>Key Findings and Conclusions</h3><p>In addition to plant-based and animal-based foods, Met can also be obtained from microbe-based foods. MR may be more easily adopted by humans without the need to restrict energy intake. MR offers multiple health benefits, including anti-obesity, anti-diabetic, anti-cancer, cardiovascular protective, and neuroprotective effects. These benefits stem from its impact on various regulatory mechanisms, such as one-carbon metabolism, oxidative stress, mTOR signaling, IGF-I signaling, FGF21 and H<sub>2</sub>S production, epigenetics, and regulation of short-chain fatty acids (SCFAs). N-Hcy-protein is associated with various Hcy pathologies, and MR may effectively block its formation. Clinical trials have demonstrated the efficacy of MR in treating obesity and cancer, highlighting the need for further exploration of its therapeutic potential. Overall, MR diets show promise for the preventing of certain chronic human diseases.</p></div>\",\"PeriodicalId\":441,\"journal\":{\"name\":\"Trends in Food Science & Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":15.1000,\"publicationDate\":\"2024-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Food Science & Technology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0924224424002085\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Food Science & Technology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0924224424002085","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Methionine Restriction Diets: Unravelling Biological Mechanisms and Enhancing Brain Health
Background
Methionine (Met) uptake and metabolism are integral to various cellular functions. Excessive intake of Met from human diets can lead to numerous health issues. Conversely, methionine restriction (MR) diets have recently gained considerable attention due to their diverse bioactivities. These include anti-cancer, anti-aging and anti-inflammatory, anti-obesity, cardiovascular protection, intestinal improvement, liver protection, brain health improvement, and other effects. The effectiveness of MR in exerting these bioactivities is closely linked to the modulation of critical molecular targets.
Scope and Approach
This review offers a thorough and current examination of Met food sources, Met metabolism, the beneficial functions, particularly in brain health, and potential adverse effects of MR diets, along with their underlying molecular mechanisms. Specifically, the impact of MR diets on homocysteine (Hcy) metabolism.
Key Findings and Conclusions
In addition to plant-based and animal-based foods, Met can also be obtained from microbe-based foods. MR may be more easily adopted by humans without the need to restrict energy intake. MR offers multiple health benefits, including anti-obesity, anti-diabetic, anti-cancer, cardiovascular protective, and neuroprotective effects. These benefits stem from its impact on various regulatory mechanisms, such as one-carbon metabolism, oxidative stress, mTOR signaling, IGF-I signaling, FGF21 and H2S production, epigenetics, and regulation of short-chain fatty acids (SCFAs). N-Hcy-protein is associated with various Hcy pathologies, and MR may effectively block its formation. Clinical trials have demonstrated the efficacy of MR in treating obesity and cancer, highlighting the need for further exploration of its therapeutic potential. Overall, MR diets show promise for the preventing of certain chronic human diseases.
期刊介绍:
Trends in Food Science & Technology is a prestigious international journal that specializes in peer-reviewed articles covering the latest advancements in technology, food science, and human nutrition. It serves as a bridge between specialized primary journals and general trade magazines, providing readable and scientifically rigorous reviews and commentaries on current research developments and their potential applications in the food industry.
Unlike traditional journals, Trends in Food Science & Technology does not publish original research papers. Instead, it focuses on critical and comprehensive reviews to offer valuable insights for professionals in the field. By bringing together cutting-edge research and industry applications, this journal plays a vital role in disseminating knowledge and facilitating advancements in the food science and technology sector.