啮齿动物痛觉感受器中 Piezo2 的新型抑制因子

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-07-01 Epub Date: 2024-05-17 DOI:10.1016/j.tins.2024.05.003

Aaron Keith West, Eve Rebecca Schneider

引用次数: 0

摘要

压电和跨膜通道样（TMC）家族的成员都是哺乳动物真正的机械传导者。在最近的一项研究中，Zhang、Shao 等人发现 TMC7（一种对机械不敏感的 TMC）会抑制 Piezo2 依赖性机械感觉，这意味着 Piezo2 通道的细胞环境在正常和病理机械痛反应中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A novel suppressor of Piezo2 in rodent nociceptors.

Members of both the Piezo and transmembrane channel-like (TMC) families are bona fide mammalian mechanotransducers. In a recent study, Zhang, Shao et al. discovered that TMC7, a non-mechanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance of cellular context for Piezo2 channels in normal and pathological responses to mechanical pain.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.