氧化平衡评分越高，勃起功能障碍的风险越低：一项基于人群的研究。

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-05-17 DOI:10.1186/s12937-024-00956-y

Zhixiao Xu, Weiwei Chu, Xiong Lei, Chengshui Chen

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引用次数: 0

摘要

背景：勃起功能障碍（ED）是一种被认为受氧化应激严重影响的常见疾病。氧化平衡评分（OBS）被用来描述抗氧化剂/促氧化剂的平衡状态。但人们对 OBS 与 ED 的关系知之甚少：本研究对 2001 年至 2004 年参加美国国家健康与营养调查（NHANES）的 1860 名男性进行了横断面分析。OBS由16种饮食成分和4种生活方式因素构成。自我报告的 ED 定义为男性表示 "从未 "或 "有时 "能达到或保持勃起以满足性交需要。采用多变量逻辑回归模型研究 OBS 与 ED 风险之间的关系：在 1860 名参与者中，OBS 的中位数为 20（IQR 15-26），有 ED 的男性与无 ED 的男性相比，OBS 更低（P = 0.001）。我们的分析结果表明，在男性受试者中，OBS 与 ED 之间存在负相关。具体来说，在经过全面调整后，连续 OBS 每增加一个单位，ED 发生几率就会降低 3%。此外，在对极端 OBS 四分位数进行比较时，经全面调整后，第 4 个 OBS 类别的调整后几率比（95% 置信区间）为 0.53（0.32 至 0.88）（P 为趋势结论）：较高的 OBS 与美国男性 ED 风险的降低有关。这些研究结果表明，采用富含抗氧化剂的饮食和参与促进抗氧化剂的生活方式可能有助于降低 ED 的发病率。这些结果为 ED 患者提供了全面的饮食和生活方式抗氧化剂建议。

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Higher oxidative balance score was associated with decreased risk of erectile dysfunction: a population-based study.

Background: Erectile dysfunction (ED) is a prevalent condition that is thought to be significantly impacted by oxidative stress. The oxidative balance score (OBS) has been built to characterize the state of antioxidant/pro-oxidant balance. There is less known regarding the relationship of OBS with ED.

Methods: This study conducted cross-sectional analyses on 1860 males who participated in the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004. OBS was constructed by the 16 dietary components and 4 lifestyle factors. Self-reported ED was defined as men who indicated that they "never" or "sometimes" could achieve or keeping an erection adequate for satisfactory intercourse. Multivariate logistic regression models were applied to examine the association between OBS and the risk of ED.

Results: Among 1860 participants, the median OBS was 20 (IQR 15-26), and OBS was lower in males with ED vs. those without ED (P = 0.001). The results of our analyses indicated a negative correlation between OBS and ED among male subjects. Specifically, each one-unit increase in the continuous OBS was relate to 3% reduction in the odds of ED after full adjustment. Moreover, when extreme OBS quartiles were compared, the adjusted odds ratio (95% confidence interval) for the 4th OBS category was 0.53 (0.32 to 0.88) after full adjustment (P for trend < 0.05). There was also statistical significance in the relationships between dietary/lifestyle OBS with ED, and the association between lifestyle OBS and ED may be even tighter. For each unit increase in lifestyle OBS, the odds of ED decreased by 11% after full adjustment.

Conclusion: Higher OBS was associated with reduced risk of ED in U.S. males. These findings suggested that adopting an antioxidant-rich diet and engaging in antioxidant-promoting lifestyle behaviors may contribute to a lower incidence of ED. These results provided recommendations for a comprehensive dietary and lifestyle antioxidants for ED patients.

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.