肥大细胞与伤口愈合:仍是一个未解之谜。

IF 2.5 4区 生物学 Q3 CELL BIOLOGY
Histology and histopathology Pub Date : 2025-01-01 Epub Date: 2024-05-06 DOI:10.14670/HH-18-757
Montserrat Fernández-Guarino, Stefano Bacci
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引用次数: 0

摘要

肥大细胞源自骨髓,能够分泌多种活性分子。这些分子包括数十年前就已发现并储存在特定颗粒中的介质(组胺、肝素)、受刺激时瞬间产生的小分子(膜脂衍生物、一氧化氮)以及连续分泌的多种多功能细胞因子。活化的肥大细胞参与调节局部免疫反应,并在大量介质的帮助下控制炎症和愈合的关键事件。这些细胞类型在炎症状态中的参与表明,肥大细胞可能充当哨兵,在各种刺激和抗原进入时激活局部免疫过程。此外,由于肥大细胞靠近神经纤维并对多种神经递质有反应,它们也是可能促进局部神经免疫相互作用的细胞之一。有鉴于此,有必要考虑它们在急性和慢性损伤修复中的参与情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mast cells and wound healing: Still an open question.

Mast cells, which originate from the bone marrow, possess the ability to secrete a diverse array of active molecules. These molecules include mediators (histamine, heparin), which have been identified for decades and are stored in specific granules, as well as small molecules generated instantaneously in response to stimulation (membrane lipid derivatives, nitric oxide), and a multitude of multifunctional cytokines that are secreted constitutively. Activated mast cells participate in the regulation of the local immune response and exert control over critical events of inflammation and healing with the assistance of a vast array of mediators. The involvement of these cell types in inflammatory states suggests that mast cells may function as sentinels that activate local immune processes in response to various types of stimuli and the entry of antigens. Moreover, due to their proximity to nerve fibers and reactivity to a variety of neurotransmitters, mast cells are among the cells that may facilitate local neuroimmune interactions. With this in mind, it is necessary to consider their participation in the repair of injuries in both acute and chronic conditions.

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来源期刊
Histology and histopathology
Histology and histopathology 生物-病理学
CiteScore
3.90
自引率
0.00%
发文量
232
审稿时长
2 months
期刊介绍: HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.
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