来自旱莲草霍尔姆斯的酶能α-亚麻酸合成共轭四烯酸--帕利那酸

IF 1.6 4区农林科学 Q3 CHEMISTRY, APPLIED

Journal of oleo science Pub Date : 2024-05-01 DOI:10.5650/jos.ess23209

Hisaaki Ito, Taro Honma, Hidetsugu Tabata, Tomoyuki Koyama, Shigeaki Ueno, Kayoko Kita, Toshihide Suzuki

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引用次数: 0

摘要

共轭脂肪酸具有抗癌作用。因此，建立共轭脂肪酸的合成方法对战胜癌症非常重要。在此，我们尝试利用从含有共轭脂肪酸的海藻中提取的酶合成共轭脂肪酸。我们对日本周边海域 12 种海藻的脂质进行了分析，发现其中的 Padina arborescens Holmes 含有共轭脂肪酸。然后，我们利用旱莲草的酶从α-亚麻酸中合成了共轭四烯酸--parinaric 酸。这种方法有望在攻克癌症方面有多种潜在应用。

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Enzyme from Padina arborescens Holmes Synthesizes Parinaric Acid, a Conjugated Tetraenoic Fatty Acid, from α-Linolenic Acid

Conjugated fatty acids have anticancer effects. Therefore, the establishment of a synthetic method for conjugated fatty acids is important for overcoming cancer. Here, we attempted to synthesize conjugated fatty acids using enzymes extracted from seaweeds containing these fatty acids. Lipids from 12 species of seaweeds from the seas around Japan were analyzed, and Padina arborescens Holmes was found to contain conjugated fatty acids. Then, we synthesized parinaric acid, a conjugated tetraenoic acid, from α-linolenic acid using the enzyme of P. arborescens. This method is expected to have a variety of potential applications for overcoming cancer.

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来源期刊

Journal of oleo science CHEMISTRY, APPLIED-FOOD SCIENCE & TECHNOLOGY

CiteScore

3.20

自引率

6.70%

发文量

173

审稿时长

3 months

期刊介绍： The J. Oleo Sci. publishes original researches of high quality on chemistry, biochemistry and science of fats and oils such as related food products, detergents, natural products, petroleum products, lipids and related proteins and sugars. The Journal also encourages papers on chemistry and/or biochemistry as a major component combined with biological/ sensory/nutritional/toxicological evaluation related to agriculture and/or food.