多)酚对培养的哺乳动物细胞中昼夜节律时钟基因介导的代谢平衡的影响:范围综述。

IF 8 1区 医学 Q1 NUTRITION & DIETETICS
Noha Sulaimani , Michael J Houghton , Maxine P Bonham , Gary Williamson
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引用次数: 0

摘要

昼夜节律调节新陈代谢的平衡。饮食和睡眠时间等生活方式破坏了我们的昼夜节律,这与代谢紊乱的发病率增加有关。现在有大量证据表明,选定的膳食(多)酚(包括类黄酮、酚酸和单宁酸)可调节新陈代谢和昼夜节律过程。本综述通过批判性地评估哺乳动物细胞文献,评估了(多)酚对体外昼夜节律时钟基因和相关代谢平衡的影响,以及潜在的作用机制。为确保文献的全面覆盖,我们进行了系统性搜索,并确定了 43 项涉及(多)酚对细胞昼夜节律过程影响的相关研究。柑橘中的金钗素和橘皮素、绿茶中的(-)-表没食子儿茶素-3-棓酸盐、尿石素 A(一种来自水果中鞣花丹宁的肠道微生物代谢物)、姜黄素、巴伐醌、肉桂酸和白藜芦醇在低微摩尔浓度下都会影响多种类型同步细胞的昼夜节律分子过程。金钗素是一种推定的视黄酸相关孤儿受体(RORα/γ)激动剂,可诱导昼夜节律调节因子大脑和肌肉类 ARNT 1(BMAL1),并增加周期昼夜节律调节因子 2(PER2)的振幅和周期。尽管所采用的方案存在很大差异,但这些效应是显而易见的,本综述提出了一个方法框架,以帮助今后在这一新兴研究领域进行研究设计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of (Poly)phenols on Circadian Clock Gene–Mediated Metabolic Homeostasis in Cultured Mammalian Cells: A Scoping Review

Circadian clocks regulate metabolic homeostasis. Disruption to our circadian clocks, by lifestyle behaviors such as timing of eating and sleeping, has been linked to increased rates of metabolic disorders. There is now considerable evidence that selected dietary (poly)phenols, including flavonoids, phenolic acids and tannins, may modulate metabolic and circadian processes. This review evaluates the effects of (poly)phenols on circadian clock genes and linked metabolic homeostasis in vitro, and potential mechanisms of action, by critically evaluating the literature on mammalian cells. A systematic search was conducted to ensure full coverage of the literature and identified 43 relevant studies addressing the effects of (poly)phenols on cellular circadian processes. Nobiletin and tangeretin, found in citrus, (–)-epigallocatechin-3-gallate from green tea, urolithin A, a gut microbial metabolite from ellagitannins in fruit, curcumin, bavachalcone, cinnamic acid, and resveratrol at low micromolar concentrations all affect circadian molecular processes in multiple types of synchronized cells. Nobiletin emerges as a putative retinoic acid–related orphan receptor (RORα/γ) agonist, leading to induction of the circadian regulator brain and muscle ARNT-like 1 (BMAL1), and increased period circadian regulator 2 (PER2) amplitude and period. These effects are clear despite substantial variations in the protocols employed, and this review suggests a methodological framework to help future study design in this emerging area of research.

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来源期刊
Advances in Nutrition
Advances in Nutrition 医学-营养学
CiteScore
17.40
自引率
2.20%
发文量
117
审稿时长
56 days
期刊介绍: Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.
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