神经元纤毛--一种高度多样化的动态细胞器，参与感觉检测和神经调节

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-04-04 DOI:10.1016/j.tins.2024.03.004

Nathalie Jurisch-Yaksi, Dagmar Wachten, Jay Gopalakrishnan

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引用次数: 0

摘要

纤毛是一种神奇的细胞器，它就像细胞的触角，能感知细胞环境。20 世纪 90 年代末，纤毛的功能障碍与被称为纤毛病的遗传疾病相关联，从而引起了人们的极大关注。从那时起，一些突破性发现揭示了纤毛生物发生和功能的基本机制。与动物界的大多数细胞一样，神经元也有纤毛，其中富含神经调节受体。然而，人们对神经元纤毛如何调节神经元生理和动物行为仍然知之甚少。通过比较感觉系统和中枢神经系统（CNS）的纤毛生物学，我们为纤毛在大脑生理学中的功能提供了新的视角。

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The neuronal cilium – a highly diverse and dynamic organelle involved in sensory detection and neuromodulation

Cilia are fascinating organelles that act as cellular antennae, sensing the cellular environment. Cilia gained significant attention in the late 1990s after their dysfunction was linked to genetic diseases known as ciliopathies. Since then, several breakthrough discoveries have uncovered the mechanisms underlying cilia biogenesis and function. Like most cells in the animal kingdom, neurons also harbor cilia, which are enriched in neuromodulatory receptors. Yet, how neuronal cilia modulate neuronal physiology and animal behavior remains poorly understood. By comparing ciliary biology between the sensory and central nervous systems (CNS), we provide new perspectives on the functions of cilia in brain physiology.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.