视觉剥夺下视神经 Ranvier 节结构的恢复

IF 2.4 4区医学 Q3 NEUROSCIENCES

Neuroscience Research Pub Date : 2024-09-01 DOI:10.1016/j.neures.2024.03.005

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引用次数: 0

摘要

神经活动会增加兰维耶节（NOR）的长度，减缓脉冲传递；然而，人们对这一具有重要生物和临床意义的恢复过程知之甚少。感觉剥夺会促进许多现象中的神经可塑性，这就提出了一个问题：NOR 形态的恢复是否会受到感觉剥夺的影响。研究结果表明，与在正常视觉经验下恢复的小鼠相比，将小鼠置于24小时黑暗环境中长达30天的双目视觉剥夺并不会显著影响小鼠视神经NOR间隙长度的恢复。这些发现有助于深入了解 NOR 可塑性的细胞机制。

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Recovery of node of ranvier structure in optic nerve under visual deprivation

Neural activity can increase the length of nodes of Ranvier (NOR) and slow impulse transmission; however, little is known about the biologically and clinically important recovery process. Sensory deprivation promotes neural plasticity in many phenomena, raising the question of whether recovery of NOR morphology is influenced by sensory deprivation. The results show that NOR gap length recovery in mouse optic nerve was not affected significantly by binocular visual deprivation imposed by maintaining mice in 24 hr dark for 30 days compared to mice recovering under normal visual experience. The findings provide insight into the cellular mechanism of NOR plasticity.

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来源期刊

Neuroscience Research 医学-神经科学

CiteScore

5.60

自引率

3.40%

发文量

136

审稿时长

28 days

期刊介绍： The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.