铁代谢、铁变态反应和疾病中的 SLC40A1:综述。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
WIREs Mechanisms of Disease Pub Date : 2024-07-01 Epub Date: 2024-03-20 DOI:10.1002/wsbm.1644
Yan Zhang, Liyi Zou, Xiaodan Li, Long Guo, Baoguang Hu, Hua Ye, Yi Liu
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引用次数: 0

摘要

溶质运载家族 40 成员 1(SLC40A1)在将铁从细胞内转运到细胞外环境中发挥着重要作用。当 SLC40A1 表达异常时,细胞铁代谢就会失调,导致细胞内铁超载,从而诱发细胞铁变态反应。大量研究证实,铁突变与许多疾病的发生密切相关。在此,我们综述了最近关于 SLC40A1 在铁氧化过程中的作用及其与多种疾病相关的研究结果,旨在探索疾病发病机制研究的新方向以及预防和治疗的新靶点。本文归类于癌症 > 遗传学/基因组学/表观遗传学 代谢性疾病 > 分子和细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SLC40A1 in iron metabolism, ferroptosis, and disease: A review.

Solute carrier family 40 member 1 (SLC40A1) plays an essential role in transporting iron from intracellular to extracellular environments. When SLC40A1 expression is abnormal, cellular iron metabolism becomes dysregulated, resulting in an overload of intracellular iron, which induces cell ferroptosis. Numerous studies have confirmed that ferroptosis is closely associated with the development of many diseases. Here, we review recent findings on SLC40A1 in ferroptosis and its association with various diseases, intending to explore new directions for research on disease pathogenesis and new therapeutic targets for prevention and treatment. This article is categorized under: Cancer > Genetics/Genomics/Epigenetics Metabolic Diseases > Molecular and Cellular Physiology.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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