中年 "大脑

IF 14.6 1区 医学 Q1 NEUROSCIENCES
Trends in Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-03-19 DOI:10.1016/j.tins.2024.02.001
Sebastian Dohm-Hansen, Jane A English, Aonghus Lavelle, Carlos P Fitzsimons, Paul J Lucassen, Yvonne M Nolan
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引用次数: 0

摘要

与老年期相比,中年期的认知能力和大脑健康衰退最为明显,但干预范围可能有限。然而,最近的研究表明,中年可能标志着大脑衰老的转变。我们回顾了多层次分析的新证据,这些证据表明,中年是一个由独特的中枢和外周过程所定义的时期,这些过程塑造了未来的认知轨迹和大脑健康。根据人类和动物模型在衰老研究和寿命研究方面的最新进展,我们强调了在研究对象年龄范围较广的样本中建立非线性变化模型的实用性,以区分特定生命阶段的过程和在整个生命周期中线性作用的过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The 'middle-aging' brain.

Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle age could mark a shift in brain aging. We review emerging evidence on multiple levels of analysis indicating that midlife is a period defined by unique central and peripheral processes that shape future cognitive trajectories and brain health. Informed by recent developments in aging research and lifespan studies in humans and animal models, we highlight the utility of modeling non-linear changes in study samples with wide subject age ranges to distinguish life stage-specific processes from those acting linearly throughout the lifespan.

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来源期刊
Trends in Neurosciences
Trends in Neurosciences 医学-神经科学
CiteScore
26.50
自引率
1.30%
发文量
123
审稿时长
6-12 weeks
期刊介绍: For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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