海洋海绵中具有 C-N 交联的环状三肽 Neopetromin 可导致烟草 BY-2 细胞中的液泡破碎。

IF 3.6 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2024-03-19 DOI:10.1021/acs.jnatprod.4c00158

Yuki Hitora, Ahmed H. El-Desoky, Yusaku Sadahiro, Ai Sejiyama, Amiri Kinoshita, Yuji Ise, Esther D. Angkouw, Remy E. P. Mangindaan, Takumi Higaki and Sachiko Tsukamoto*,

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引用次数: 0

摘要

高效液相色谱-质谱（HPLC-MS）分析表明，在海洋海绵 Neopetrosia sp.的提取物中存在一种未报道的多肽，其结构被确定为三肽，命名为 neopetromin (1)，由两个酪氨酸和一个色氨酸残基组成，侧链之间存在杂芳香族 C-N 交联。化合物 1 在烟草 BY-2 细胞中以不依赖于肌动蛋白的方式促进液泡破碎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Neopetromin, a Cyclic Tripeptide with a C–N Cross-Link, from the Marine Sponge Neopetrosia sp., That Causes Vacuole Fragmentation in Tobacco BY-2 Cells

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Neopetromin, a Cyclic Tripeptide with a C–N Cross-Link, from the Marine Sponge Neopetrosia sp., That Causes Vacuole Fragmentation in Tobacco BY-2 Cells

HPLC-MS analysis revealed the presence of an unreported peptide in the extract of the marine sponge Neopetrosia sp. Its structure was determined as a tripeptide, named neopetromin (1), composed of two tyrosine and one tryptophan residues with a heteroaromatic C–N cross-link between side chains. The absolute configuration of amino acids was determined using Marfey’s method after ozonolysis and hydrolysis of 1. Compound 1 promoted vacuole fragmentation in an actin-independent manner in tobacco BY-2 cells.

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.