对肺功能受损的 COVID-19 复发者的一年随访：前瞻性队列研究

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2024-03-16 DOI:10.1016/j.idnow.2024.104890

Nitzan Karny Epstein , Dana Yelin , Dorit Shitenberg , Dafna Yahav , Leonard Leibovici , Vered Daitch , Ili Margalit

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引用次数: 0

摘要

一氧化碳弥散能力（DLCO）降低是 COVID-19 复发者中最常见的肺部检测异常。我们在 COVID-19 后平均 3 个月对 51 名 DLCO 受损者进行了前瞻性随访，并在一年后对他们进行了复查。随访期间，DLCO 平均值从 68.0% 上升至 72.6%（p = 0.002）；虽然有 33% 的患者 DLCO 出现了临床意义上的显著上升（>10 点），但只有 29% 的患者 DLCO 值恢复正常。虽然 DLCO 的变化与症状无关，但缺乏改善在肥胖患者中更为普遍。无论 COVID-19 的严重程度如何，很大一部分人在 1 年后仍表现出 DLCO 受损。

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One-year follow-up of COVID-19 recoverees with impaired pulmonary function: A prospective cohort study

Decreased diffusion capacity for carbon monoxide (DLCO) is the most prevalent pulmonary testing abnormality among COVID-19 recoverees. We prospectively followed 51 individuals with impaired DLCO at an average of ∼3 months following COVID-19 and re-examined them at one year. At follow-up, mean DLCO increased from 68.0 % to 72.6 % (p = 0.002); while 33 % of the cohort experienced a clinically significant rise (>10 points) in DLCO, only 29 % normalized their values. While DLCO change did not correlate with symptoms, lack of improvement was more prevalent among individuals with obesity. Regardless of COVID-19 severity, a substantial proportion continued to exhibit DLCO impairment at 1-year.

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