网络游戏障碍和酒精使用障碍中基于模型行为的神经相关性。

IF 6.6 1区 医学 Q1 PSYCHIATRY
Journal of Behavioral Addictions Pub Date : 2024-03-08 Print Date: 2024-03-26 DOI:10.1556/2006.2024.00006
Mina Kwon, Hangnyoung Choi, Harhim Park, Woo-Young Ahn, Young-Chul Jung
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引用次数: 0

摘要

背景:基于模型的决策系统和无模型决策系统之间的不平衡是成瘾性障碍的一个共同特征。然而,人们对网络游戏障碍(IGD)是否也存在类似的决策缺陷知之甚少。本研究比较了 IGD 和酒精使用障碍(AUD)中与基于模型和无模型系统相关的神经认知特征:方法:被诊断为 IGD(22 人)和 AUD(22 人)的参与者以及健康对照组(30 人)在功能磁共振成像(fMRI)扫描仪内完成两阶段任务。我们利用计算建模和分层贝叶斯分析对他们的选择行为进行了机理解释。然后,我们进行了基于模型的 fMRI 分析和功能连接分析,以确定各组决策过程的神经相关性:计算建模结果显示,IGD 组和 AUD 组基于模型的行为水平相似。然而,我们观察到两组基于模型的奖赏预测误差(RPE)存在不同的神经相关性。IGD 组表现出与基于模型的 RPE 相关的胰岛特异性激活,而 AUD 组则表现出前额叶激活,尤其是在眶额皮层和额上回。此外,在基于模型的RPE背景下,IGD患者的脑岛与显著性网络中的脑区之间表现出超连接性:研究结果表明,尽管在计算建模分析中观察到了共同的认知特征,但 IGD 和 AUD 基于模型行为的神经生物学机制可能存在差异。作为第一项比较 IGD 和 AUD 基于模型系统的神经影像学研究,本研究为 IGD 的独特决策过程提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neural correlates of model-based behavior in internet gaming disorder and alcohol use disorder.

Background: An imbalance between model-based and model-free decision-making systems is a common feature in addictive disorders. However, little is known about whether similar decision-making deficits appear in internet gaming disorder (IGD). This study compared neurocognitive features associated with model-based and model-free systems in IGD and alcohol use disorder (AUD).

Method: Participants diagnosed with IGD (n = 22) and AUD (n = 22), and healthy controls (n = 30) performed the two-stage task inside the functional magnetic resonance imaging (fMRI) scanner. We used computational modeling and hierarchical Bayesian analysis to provide a mechanistic account of their choice behavior. Then, we performed a model-based fMRI analysis and functional connectivity analysis to identify neural correlates of the decision-making processes in each group.

Results: The computational modeling results showed similar levels of model-based behavior in the IGD and AUD groups. However, we observed distinct neural correlates of the model-based reward prediction error (RPE) between the two groups. The IGD group exhibited insula-specific activation associated with model-based RPE, while the AUD group showed prefrontal activation, particularly in the orbitofrontal cortex and superior frontal gyrus. Furthermore, individuals with IGD demonstrated hyper-connectivity between the insula and brain regions in the salience network in the context of model-based RPE.

Discussion and conclusions: The findings suggest potential differences in the neurobiological mechanisms underlying model-based behavior in IGD and AUD, albeit shared cognitive features observed in computational modeling analysis. As the first neuroimaging study to compare IGD and AUD in terms of the model-based system, this study provides novel insights into distinct decision-making processes in IGD.

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来源期刊
CiteScore
12.30
自引率
7.70%
发文量
91
审稿时长
20 weeks
期刊介绍: The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.
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