拉弗拉进行性肌阵挛癫痫小鼠模型的视网膜血管病理学。

IF 2.4 4区医学 Q3 NEUROSCIENCES

Neuroscience Research Pub Date : 2024-03-06 DOI:10.1016/j.neures.2024.02.004

Ruchira Pranay Patil , Nitin Kumar , Arveen Kaur , Rajendra Kumar Munian , Bishakh Bhattacharya , Subramaniam Ganesh , Rashmi Parihar

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引用次数: 0

摘要

神经退行性疾病（ND）影响不同的神经元群，表现出各种临床和病理症状。一部分神经退行性疾病的预后与血管风险因素有关。因此，本研究调查了拉弗拉神经退行性疾病（LD）鼠模型中的视网膜血管异常，LD是一种致命的遗传性进行性肌阵挛癫痫，多发于儿童。在这里，我们通过测量脉搏波速度和视网膜血管变形来评估动脉僵化情况。我们在 LD 小鼠模型中的研究结果表明，脉搏波速度发生了改变，视网膜血管变细，视网膜动脉卷曲。

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Retinal vascular pathology in a mouse model of Lafora progressive myoclonus epilepsy

Neurodegenerative diseases (ND) affect distinct populations of neurons and manifest various clinical and pathological symptoms. A subset of ND prognoses has been linked to vascular risk factors. Consequently, the current study investigated retinal vascular abnormalities in a murine model of Lafora neurodegenerative disease (LD), a fatal and genetic form of progressive myoclonus epilepsy that affects children. Here, arterial rigidity was evaluated by measuring pulse wave velocity and vasculature deformations in the retina. Our findings in the LD mouse model indicate altered pulse wave velocity, retinal vascular thinning, and convoluted retinal arteries.

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来源期刊

Neuroscience Research 医学-神经科学

CiteScore

5.60

自引率

3.40%

发文量

136

审稿时长

28 days

期刊介绍： The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.