使用甲基苯丙胺的青少年的认知功能：炎症和氧化过程的影响

IF 1.4 4区心理学 Q4 CLINICAL NEUROLOGY

Applied Neuropsychology: Child Pub Date : 2024-03-06 DOI:10.1080/21622965.2024.2323643

Burak Çakır, Aylin Deniz Uzun Çakır, Şermin Yalın Sapmaz, Öznur Bilaç, Fatma Taneli, Hasan Kandemir

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引用次数: 0

摘要

背景：甲基苯丙胺是一种会导致神经中毒的物质，近年来其使用量不断增加。文献强调使用甲基苯丙胺会导致认知障碍。本研究旨在评估患有甲基苯丙胺使用障碍的青少年认知障碍与炎症过程之间的关系：研究对象包括 69 名 15-19 岁的青少年，其中包括 37 名甲基苯丙胺使用障碍患者和 32 名健康对照者。中枢神经系统生命体征用于检测认知障碍。使用儿童创伤问卷-33 和儿童抑郁量表。此外，还采集了志愿者的静脉血。对生化指标（IL-1beta、IL-6、TNF-a、BDNF、FAM19A5、TAS、TOS）进行了分析：我们的研究表明：（I）甲基苯丙胺吸食者的IL-6和TNF-a水平低于健康组；（II）甲基苯丙胺吸食者的BDNF水平高于健康组；（III）吸食甲基苯丙胺青少年认知测试的平均神经认知指数与甲基苯丙胺吸食时间和BDNF水平呈负相关：我们的研究表明，吸食甲基苯丙胺可能会对认知功能产生负面影响。

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Cognitive functioning of adolescents using Methamphetamine: The impact of inflammatory and oxidative processes.

Background: Methamphetamine is a substance that causes neurotoxicity and its use is increasing in recent years. Literature highlights cognitive impairment resulting from Methamphetamine use. The aim of the present study is to evaluate the relationship between cognitive impairment and inflammatory processes in adolescents with Methamphetamine use disorder.

Methods: The study included 69 adolescents aged 15-19 years, comprising 37 participants with Methamphetamine Use Disorder and 32 healthy controls. Central Nervous System Vital Signs was used to detect cognitive impairment. Childhood Trauma Questionnaire-33 and The Children's Depression Inventory scales were used. In addition, venous blood was collected from the volunteers. Biochemical parameters (IL-1beta, IL-6, TNF-a, BDNF, FAM19A5, TAS, TOS) were analyzed.

Results: Our study showed that (I) IL-6 and TNF-a levels of Methamphetamine users were lower than the healthy group; (II) BDNF levels of Methamphetamine users were higher than the healthy group; (III) mean Neurocognitive Index in cognitive tests of Methamphetamine using adolescents was negatively correlated with duration of Methamphetamine use and BDNF levels.

Conclusions: Our study suggests that Methamphetamine use may have a negative effect on cognitive functions.

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来源期刊

Applied Neuropsychology: Child CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.00

自引率

5.90%

发文量

期刊介绍： Applied Neuropsychology: Child publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in children. Full-length articles and brief communications are included. Case studies of child patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.