提高药物抗癌活性的共晶技术

IF 1.5 4区材料科学 Q3 Chemistry

Crystal Research and Technology Pub Date : 2024-03-04 DOI:10.1002/crat.202300253

Amin Alvani, Ali Shayanfar

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引用次数: 0

摘要

共晶体化可以改变活性药物成分（API）的物理化学和药代动力学特性，提高其生物活性。本研究重点关注有文献记载的共晶形式原料药的生物活性，特别是那些具有抗癌特性的原料药。此外，还讨论了这些原料药表现出改良抗癌效果的机制。一般来说，这种技术可以通过增溶、提高溶解速度、改善渗透性、稳定、产生缓释形式、在溶液中保持瞬时性以及与受体相互作用等方式改变抗癌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cocrystallization for Improving Anticancer Activity of Drugs

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Cocrystallization for Improving Anticancer Activity of Drugs

Cocrystallization can change the physicochemical and pharmacokinetic properties of active pharmaceutical ingredients (API) and improve biological activities. This study focuses on the documented biological activities of APIs in cocrystal form, specifically those with anticancer properties. Additionally, the mechanisms by which these APIs exhibit modified anticancer effects are discussed. Generally, this technique can change anticancer activity through solubilization, enhancing dissolution rate, permeability improvement, stabilization, producing a slow-release form, and retaining transient in solution and interaction with receptors.

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来源期刊

Crystal Research and Technology CRYSTALLOGRAPHY-

CiteScore

2.50

自引率

6.70%

发文量

121

审稿时长

1.9 months

期刊介绍： The journal Crystal Research and Technology is a pure online Journal (since 2012). Crystal Research and Technology is an international journal examining all aspects of research within experimental, industrial, and theoretical crystallography. The journal covers the relevant aspects of -crystal growth techniques and phenomena (including bulk growth, thin films) -modern crystalline materials (e.g. smart materials, nanocrystals, quasicrystals, liquid crystals) -industrial crystallisation -application of crystals in materials science, electronics, data storage, and optics -experimental, simulation and theoretical studies of the structural properties of crystals -crystallographic computing