导致日本双胞胎甲髌综合征的 LMX1B 基因缺失变异。

IF 1 Q4 GENETICS & HEREDITY
Nozomu Kishio, Kazuhiro Iwama, Sayuri Nakanishi, Ryosuke Shindo, Masaki Yasui, Naoki Nicho, Atsushi Takahashi, Mana Kohara, Michisato Hirata, Takahiro Kemmotsu, Miki Tanoshima, Shuichi Ito
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引用次数: 0

摘要

指甲-风疹综合征(NPS)是一种由 LMX1B 致病变体引起的遗传性疾病,以指甲、四肢和肾脏症状为特征。这项研究在患有足癣的日本双胞胎中发现了一个可能致病的 LMX1B 变异基因 NM_002316.4:c.723_726delinsC (p.Ser242del)。p.Ser242del位于该蛋白的同源结构域,而导致肾病的变异往往聚集在该结构域。我们的研究结果突显了p.Ser242del可能是一种致病变体,从而扩展了我们对NPS的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A deletion variant in LMX1B causing nail-patella syndrome in Japanese twins.

A deletion variant in LMX1B causing nail-patella syndrome in Japanese twins.

Nail-patella syndrome (NPS) is a hereditary disease caused by pathogenic variants in LMX1B and characterized by nail, limb, and renal symptoms. This study revealed a likely pathogenic LMX1B variant, NM_002316.4: c.723_726delinsC (p.Ser242del), in Japanese twins with clubfoot. The patients' mother, who shared this variant, developed proteinuria after delivery. p.Ser242del is located in the homeodomain of the protein, in which variants that cause renal disease tend to cluster. Our findings highlight p.Ser242del as a likely pathogenic variant, expanding our knowledge of NPS.

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来源期刊
Human Genome Variation
Human Genome Variation Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
2.30
自引率
0.00%
发文量
39
审稿时长
13 weeks
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