HHEX 多态性与首发精神分裂症患者延迟记忆之间的关系

IF 2.3 Q2 PSYCHIATRY
Zhen Hua Zhu , Xu Yuan Yin , Yuan Cai , Ning Ning Jia, Pei Jie Wang, Qi Qi, Wen Long Hou, Li Juan Man, Li Hui
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引用次数: 0

摘要

造血表达的同工酶基因(HHEX)在调节免疫系统中发挥着关键作用,其异常参与了精神疾病的精神病理学和认知障碍。本研究旨在探讨 HHEX rs1111875 多态性对首发精神分裂症患者(FSP)易感性和认知缺陷的影响。我们使用神经心理状态评估可重复性电池(RBANS)评估了 239 名符合 DSM-IV 精神分裂症的首发患者和 368 名健康对照者的认知功能。对 HHEX rs1111875 多态性进行了基因分型。结果显示,在对性别和年龄进行调整后,HHEX rs1111875多态性的等位基因频率和基因型频率在FSP和健康对照组之间没有差异(均为p > 0.05)。经协变因素调整后,除了视觉空间/结构得分(p >0.05)外,FSP 的认知测试得分在所有量表上都明显低于健康对照组(均 p <0.001)。在调整协变量后,基因型(p <0.05)而非基因型 × 诊断(p >0.05)对延迟记忆得分有明显影响。在调整协变量后,HHEX rs1111875多态性与FSP的延迟记忆得分显著相关(p <0.05),但与健康对照组无关(p >0.05)。我们的研究结果表明,HHEX rs1111875 多态性不会导致 FSP 易感性。然而,该多态性可能会影响 FSP 的延迟记忆。此外,与健康对照组相比,FSP 的认知功能较差,但视觉空间/结构领域除外。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between the HHEX polymorphism and delayed memory in first-episode schizophrenic patients

The hematopoietically-expressed homeobox gene (HHEX) played a critical role in regulating the immune system that the abnormality of which was involved in the psychopathology and cognitive deficits of psychiatric disorders. The aim of this study was to investigate the effect of HHEX rs1111875 polymorphism on the susceptibility and cognitive deficits of first-episode schizophrenic patients (FSP). We assessed cognitive function in 239 first-episode patients meeting DSM-IV for schizophrenia, and 368 healthy controls using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The HHEX rs1111875 polymorphism was genotyped. Our results showed that the allelic and genotypic frequencies of HHEX rs1111875 polymorphism didn't differ between FSP and healthy controls (both p > 0.05) after adjusting for sex and age. Cognitive test scores in FSP were significantly lower than those in healthy controls on all scales (all p < 0.001) except for the visuospatial/constructional score (p > 0.05) after adjusting for covariates. There was a significant genotype (p < 0.05) rather than genotype × diagnosis (p > 0.05) effect on the delayed memory score after adjusting for covariates. The HHEX rs1111875 polymorphism was significantly associated with the delayed memory score in FSP (p < 0.05), but not in healthy controls (p > 0.05) after adjusting for covariates. Our findings supported that the HHEX rs1111875 polymorphism did not contribute to the susceptibility to FSP. However, this polymorphism might influence the delayed memory in FSP. Moreover, FSP had poorer cognitive function than healthy controls except for the visuospatial/constructional domain.

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来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
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