Carlos E. Fernández-García , Juan Gallego-Galiana , Pablo A. Solís-Muñoz , Elvira del Pozo-Maroto , Lucía Domínguez-Alcón , Milagros Tobar-Izquierdo , Alicia Sáez , Javier Rodríguez de Cía , Amelia Magaña-Sánchez , Yolanda Real-Martínez , Luisa García-Buey , Leticia González-Moreno , María Caldas-Álvarez , Laura M. Cardeñoso-Domingo , Amelia González-Gamarra , Antonio Salvador-Calvo , Águeda González-Rodríguez , Carmelo García-Monzón
{"title":"在实现丙型肝炎病毒微量清除方面，医院筛查优于初级保健筛查。","authors":"Carlos E. Fernández-García , Juan Gallego-Galiana , Pablo A. Solís-Muñoz , Elvira del Pozo-Maroto , Lucía Domínguez-Alcón , Milagros Tobar-Izquierdo , Alicia Sáez , Javier Rodríguez de Cía , Amelia Magaña-Sánchez , Yolanda Real-Martínez , Luisa García-Buey , Leticia González-Moreno , María Caldas-Álvarez , Laura M. Cardeñoso-Domingo , Amelia González-Gamarra , Antonio Salvador-Calvo , Águeda González-Rodríguez , Carmelo García-Monzón","doi":"10.1016/j.idnow.2024.104855","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>To assess the respective performances of a HCV screening program in a hospital setting and a HCV screening model applied concomitantly in a primary care centre.</p></div><div><h3>Methods</h3><p>Adult patients consecutively admitted to hospital for ambulatory surgery were screened for anti-HCV antibodies (hospital screening cohort, HPSC), as were patients receiving blood tests for medical reasons in a primary care centre (primary care screening cohort, PCSC). Serum anti-HCV and HCV RNA levels were tested by ELISA and real-time PCR, respectively.</p></div><div><h3>Results</h3><p>Seroprevalence of HCV infection was 2.2 % in the HPSC and 1.4 % in the PCSC (p = 0.044). All viraemic patients (0.2 % in HPSC and 0.1 % in PCSC) were treated with direct-acting antivirals and 85.7 % experienced a sustained virological response.</p></div><div><h3>Conclusions</h3><p>Hospital-based HCV screening outperformed primary care-centered screening, significantly increasing HCV case findings.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 2","pages":"Article 104855"},"PeriodicalIF":2.9000,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000101/pdfft?md5=c03668c3b006632cf9766ef829b4c63c&pid=1-s2.0-S2666991924000101-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Hospital-based screening outperforms primary care screening as a means of achieving hepatitis C virus micro-elimination\",\"authors\":\"Carlos E. Fernández-García , Juan Gallego-Galiana , Pablo A. Solís-Muñoz , Elvira del Pozo-Maroto , Lucía Domínguez-Alcón , Milagros Tobar-Izquierdo , Alicia Sáez , Javier Rodríguez de Cía , Amelia Magaña-Sánchez , Yolanda Real-Martínez , Luisa García-Buey , Leticia González-Moreno , María Caldas-Álvarez , Laura M. Cardeñoso-Domingo , Amelia González-Gamarra , Antonio Salvador-Calvo , Águeda González-Rodríguez , Carmelo García-Monzón\",\"doi\":\"10.1016/j.idnow.2024.104855\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>To assess the respective performances of a HCV screening program in a hospital setting and a HCV screening model applied concomitantly in a primary care centre.</p></div><div><h3>Methods</h3><p>Adult patients consecutively admitted to hospital for ambulatory surgery were screened for anti-HCV antibodies (hospital screening cohort, HPSC), as were patients receiving blood tests for medical reasons in a primary care centre (primary care screening cohort, PCSC). Serum anti-HCV and HCV RNA levels were tested by ELISA and real-time PCR, respectively.</p></div><div><h3>Results</h3><p>Seroprevalence of HCV infection was 2.2 % in the HPSC and 1.4 % in the PCSC (p = 0.044). All viraemic patients (0.2 % in HPSC and 0.1 % in PCSC) were treated with direct-acting antivirals and 85.7 % experienced a sustained virological response.</p></div><div><h3>Conclusions</h3><p>Hospital-based HCV screening outperformed primary care-centered screening, significantly increasing HCV case findings.</p></div>\",\"PeriodicalId\":13539,\"journal\":{\"name\":\"Infectious diseases now\",\"volume\":\"54 2\",\"pages\":\"Article 104855\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666991924000101/pdfft?md5=c03668c3b006632cf9766ef829b4c63c&pid=1-s2.0-S2666991924000101-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious diseases now\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666991924000101\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases now","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666991924000101","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Hospital-based screening outperforms primary care screening as a means of achieving hepatitis C virus micro-elimination
Aim
To assess the respective performances of a HCV screening program in a hospital setting and a HCV screening model applied concomitantly in a primary care centre.
Methods
Adult patients consecutively admitted to hospital for ambulatory surgery were screened for anti-HCV antibodies (hospital screening cohort, HPSC), as were patients receiving blood tests for medical reasons in a primary care centre (primary care screening cohort, PCSC). Serum anti-HCV and HCV RNA levels were tested by ELISA and real-time PCR, respectively.
Results
Seroprevalence of HCV infection was 2.2 % in the HPSC and 1.4 % in the PCSC (p = 0.044). All viraemic patients (0.2 % in HPSC and 0.1 % in PCSC) were treated with direct-acting antivirals and 85.7 % experienced a sustained virological response.
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