7 T fMRI揭示猕猴腹侧和背侧视觉通路的中尺度组织结构

IF 6.7 2区 医学 Q1 NEUROSCIENCES
Jianbao Wang , Xiao Du , Songping Yao , Lihui Li , Hisashi Tanigawa , Xiaotong Zhang , Anna Wang Roe
{"title":"7 T fMRI揭示猕猴腹侧和背侧视觉通路的中尺度组织结构","authors":"Jianbao Wang ,&nbsp;Xiao Du ,&nbsp;Songping Yao ,&nbsp;Lihui Li ,&nbsp;Hisashi Tanigawa ,&nbsp;Xiaotong Zhang ,&nbsp;Anna Wang Roe","doi":"10.1016/j.pneurobio.2024.102584","DOIUrl":null,"url":null,"abstract":"<div><p>In human and nonhuman primate brains, columnar (mesoscale) organization has been demonstrated to underlie both lower and higher order aspects of visual information processing. Previous studies have focused on identifying functional preferences of mesoscale domains in specific areas; but there has been little understanding of how mesoscale domains may cooperatively respond to single visual stimuli across dorsal and ventral pathways. Here, we have developed ultrahigh-field 7 T fMRI methods to enable simultaneous mapping, in individual macaque monkeys, of response in both dorsal and ventral pathways to single simple color and motion stimuli. We provide the first evidence that anatomical V2 cytochrome oxidase-stained stripes are well aligned with fMRI maps of V2 stripes, settling a long-standing controversy. In the ventral pathway, a systematic array of paired color and luminance processing domains across V4 was revealed, suggesting a novel organization for surface information processing. In the dorsal pathway, in addition to high quality motion direction maps of MT, MST and V3A, alternating color and motion direction domains in V3 are revealed. As well, submillimeter motion domains were observed in peripheral LIPd and LIPv. In sum, our study provides a novel global snapshot of how mesoscale networks in the ventral and dorsal visual pathways form the organizational basis of visual objection recognition and vision for action.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":null,"pages":null},"PeriodicalIF":6.7000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301008224000200/pdfft?md5=07dcf6174ef25060bc337fe8ff6ae01b&pid=1-s2.0-S0301008224000200-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Mesoscale organization of ventral and dorsal visual pathways in macaque monkey revealed by 7T fMRI\",\"authors\":\"Jianbao Wang ,&nbsp;Xiao Du ,&nbsp;Songping Yao ,&nbsp;Lihui Li ,&nbsp;Hisashi Tanigawa ,&nbsp;Xiaotong Zhang ,&nbsp;Anna Wang Roe\",\"doi\":\"10.1016/j.pneurobio.2024.102584\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In human and nonhuman primate brains, columnar (mesoscale) organization has been demonstrated to underlie both lower and higher order aspects of visual information processing. Previous studies have focused on identifying functional preferences of mesoscale domains in specific areas; but there has been little understanding of how mesoscale domains may cooperatively respond to single visual stimuli across dorsal and ventral pathways. Here, we have developed ultrahigh-field 7 T fMRI methods to enable simultaneous mapping, in individual macaque monkeys, of response in both dorsal and ventral pathways to single simple color and motion stimuli. We provide the first evidence that anatomical V2 cytochrome oxidase-stained stripes are well aligned with fMRI maps of V2 stripes, settling a long-standing controversy. In the ventral pathway, a systematic array of paired color and luminance processing domains across V4 was revealed, suggesting a novel organization for surface information processing. In the dorsal pathway, in addition to high quality motion direction maps of MT, MST and V3A, alternating color and motion direction domains in V3 are revealed. As well, submillimeter motion domains were observed in peripheral LIPd and LIPv. In sum, our study provides a novel global snapshot of how mesoscale networks in the ventral and dorsal visual pathways form the organizational basis of visual objection recognition and vision for action.</p></div>\",\"PeriodicalId\":20851,\"journal\":{\"name\":\"Progress in Neurobiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.7000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0301008224000200/pdfft?md5=07dcf6174ef25060bc337fe8ff6ae01b&pid=1-s2.0-S0301008224000200-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Neurobiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0301008224000200\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0301008224000200","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

在人类和非人灵长类动物的大脑中,柱状(中尺度)组织已被证明是视觉信息处理的低阶和高阶方面的基础。以往的研究主要集中于识别特定区域中尺度结构域的功能偏好;但对于中尺度结构域如何在背侧和腹侧通路上对单一视觉刺激做出协同反应,研究人员还知之甚少。在这里,我们开发了超高场 7 T fMRI 方法,可以在单个猕猴体内同时绘制背侧和腹侧通路对单一简单颜色和运动刺激的反应图。我们首次证明了解剖学上的 V2 细胞色素氧化酶染色条纹与 V2 条纹的 fMRI 图谱非常吻合,从而解决了一个长期存在的争议。在腹侧通路中,发现了整个V4的成对颜色和亮度处理域的系统排列,这表明表面信息处理有了新的组织。在背侧通路中,除了 MT、MST 和 V3A 的高质量运动方向图外,还发现了 V3 中交替的颜色和运动方向域。总之,我们的研究为腹侧和背侧视觉通路的中尺度网络如何形成视觉异议识别和行动视觉的组织基础提供了一个新颖的全球快照。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mesoscale organization of ventral and dorsal visual pathways in macaque monkey revealed by 7T fMRI

In human and nonhuman primate brains, columnar (mesoscale) organization has been demonstrated to underlie both lower and higher order aspects of visual information processing. Previous studies have focused on identifying functional preferences of mesoscale domains in specific areas; but there has been little understanding of how mesoscale domains may cooperatively respond to single visual stimuli across dorsal and ventral pathways. Here, we have developed ultrahigh-field 7 T fMRI methods to enable simultaneous mapping, in individual macaque monkeys, of response in both dorsal and ventral pathways to single simple color and motion stimuli. We provide the first evidence that anatomical V2 cytochrome oxidase-stained stripes are well aligned with fMRI maps of V2 stripes, settling a long-standing controversy. In the ventral pathway, a systematic array of paired color and luminance processing domains across V4 was revealed, suggesting a novel organization for surface information processing. In the dorsal pathway, in addition to high quality motion direction maps of MT, MST and V3A, alternating color and motion direction domains in V3 are revealed. As well, submillimeter motion domains were observed in peripheral LIPd and LIPv. In sum, our study provides a novel global snapshot of how mesoscale networks in the ventral and dorsal visual pathways form the organizational basis of visual objection recognition and vision for action.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Progress in Neurobiology
Progress in Neurobiology 医学-神经科学
CiteScore
12.80
自引率
1.50%
发文量
107
审稿时长
33 days
期刊介绍: Progress in Neurobiology is an international journal that publishes groundbreaking original research, comprehensive review articles and opinion pieces written by leading researchers. The journal welcomes contributions from the broad field of neuroscience that apply neurophysiological, biochemical, pharmacological, molecular biological, anatomical, computational and behavioral analyses to problems of molecular, cellular, developmental, systems, and clinical neuroscience.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信