预防和控制整个生命过程中的锌缺乏症:行动呼吁。

IF 8 1区 医学 Q1 NUTRITION & DIETETICS
Nicola M Lowe , Andrew G Hall , Martin R Broadley , Jennifer Foley , Erick Boy , Zulfiqar A Bhutta
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引用次数: 0

摘要

锌的作用多种多样,与其他任何一种微量营养素相比,锌决定着更多的关键生命功能。锌对儿童生长和抗感染的重要性已得到公认,除此之外,锌还在调节葡萄糖代谢方面发挥着许多特殊作用,越来越多的证据表明,缺锌会增加糖尿病和心脏代谢疾病的风险。因此,锌营养对人的一生健康至关重要。缺锌也是全球最常见的微量营养素营养不良形式之一。如果考虑到缺锌对全球空腹血糖升高和相关非传染性疾病(NCDs)的影响,就能更清楚地估计成年和晚年生活中因缺锌造成的健康差异负担。然而,部分由于缺乏评估人体锌状况的敏感和特异性方法,在降低锌缺乏症发病率方面取得的进展有限。这篇叙述性综述涵盖了我们对锌在健康中的作用的最新认识进展;不断变化的气候和全球环境对锌摄入量的影响;新型功能性生物标志物显示出监测人群干预措施的前景;以及改善人群锌摄入量的解决方案。它旨在推动实施循证干预措施,预防和控制整个生命过程中的锌缺乏症。提高锌的摄入量和防治全球锌缺乏症需要根据具体情况采取相应的策略,并将补充剂、食品营养强化、生物强化等食品和农业解决方案等以证据为基础的补充性干预措施结合起来,同时努力提高锌的生物利用率。通过锌生物强化提高膳食锌含量和生物利用率是一种包容性的营养解决方案,可以最大程度地惠及受膳食不足影响的最弱势个人和人群。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preventing and Controlling Zinc Deficiency Across the Life Course: A Call to Action

Through diverse roles, zinc determines a greater number of critical life functions than any other single micronutrient. Beyond the well-recognized importance of zinc for child growth and resistance to infections, zinc has numerous specific roles covering the regulation of glucose metabolism, and growing evidence links zinc deficiency with increased risk of diabetes and cardiometabolic disorders. Zinc nutriture is, thus, vitally important to health across the life course. Zinc deficiency is also one of the most common forms of micronutrient malnutrition globally. A clearer estimate of the burden of health disparity attributable to zinc deficiency in adulthood and later life emerges when accounting for its contribution to global elevated fasting blood glucose and related noncommunicable diseases (NCDs). Yet progress attenuating its prevalence has been limited due, in part, to the lack of sensitive and specific methods to assess human zinc status. This narrative review covers recent developments in our understanding of zinc’s role in health, the impact of the changing climate and global context on zinc intake, novel functional biomarkers showing promise for monitoring population-level interventions, and solutions for improving population zinc intake. It aims to spur on implementation of evidence-based interventions for preventing and controlling zinc deficiency across the life course. Increasing zinc intake and combating global zinc deficiency requires context-specific strategies and a combination of complementary, evidence-based interventions, including supplementation, food fortification, and food and agricultural solutions such as biofortification, alongside efforts to improve zinc bioavailability. Enhancing dietary zinc content and bioavailability through zinc biofortification is an inclusive nutrition solution that can benefit the most vulnerable individuals and populations affected by inadequate diets to the greatest extent.

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来源期刊
Advances in Nutrition
Advances in Nutrition 医学-营养学
CiteScore
17.40
自引率
2.20%
发文量
117
审稿时长
56 days
期刊介绍: Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.
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