赌博障碍和相关表型的遗传学：多基因和多因素风险模型在早期检测和改善临床结果方面的潜在用途。

IF 6.6 1区医学 Q1 PSYCHIATRY

Journal of Behavioral Addictions Pub Date : 2024-01-15 Print Date: 2024-03-26 DOI:10.1556/2006.2023.00075

Varun Warrier, Samuel R Chamberlain, Shane A Thomas, Henrietta Bowden-Jones

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引用次数: 0

摘要

赌博障碍（GD）是一种影响深远的行为成瘾，其背后似乎存在遗传因素。双生子研究显示，GD 的遗传率很高，而代际传递则显示出很高的传递率。多基因和多因素风险预测模型的最新发展为早期识别和干预高危人群提供了大好机会。GD 患者在诊断和随后的求助过程中往往会出现严重的延误，这可能会影响他们的康复。在本文中，我们主张对多基因和多因素风险建模在 GD 研究和治疗项目中的实用性进行更多研究，并对其成本和收益进行严格评估。

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Genetics of gambling disorder and related phenotypes: The potential uses of polygenic and multifactorial risk models to enable early detection and improve clinical outcomes.

Gambling Disorder (GD) is an impactful behavioural addiction for which there appear to be underpinning genetic contributors. Twin studies show significant GD heritability results and intergenerational transmission show high rates of transmission. Recent developments in polygenic and multifactorial risk prediction modelling provide promising opportunities to enable early identification and intervention for at risk individuals. People with GD often have significant delays in diagnosis and subsequent help-seeking that can compromise their recovery. In this paper we advocate for more research into the utility of polygenic and multifactorial risk modelling in GD research and treatment programs and rigorous evaluation of its costs and benefits.

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来源期刊

Journal of Behavioral Addictions PSYCHIATRY-

CiteScore

12.30

自引率

7.70%

发文量

审稿时长

20 weeks

期刊介绍： The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.