干酪乳杆菌代谢物对肠出血性大肠杆菌表达志贺毒素和中和志贺毒素的影响

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Probiotics and Antimicrobial Proteins Pub Date : 2025-06-01 Epub Date: 2024-01-15 DOI:10.1007/s12602-024-10212-8

Arpita Aditya, Zajeba Tabashsum, Zabdiel Alvarado Martinez, Debabrata Biswas

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引用次数: 0

摘要

志贺毒素（stx）由肠出血性大肠杆菌（EHEC）或志贺氏菌产生，可导致人类溶血性尿毒症（HUS）。建议通过免疫支持策略来治疗 EHEC 导致的疾病，而不是使用抗生素治疗。广泛使用的益生菌干酪乳杆菌会产生许多生物活性代谢产物，即共轭亚油酸（CLA），这些代谢产物具有增强宿主免疫力、控制 EHEC 生长及其毒力基因表达的潜力。这项研究发现，干酪乳杆菌的总代谢产物对含有 Gb3 受体的哺乳动物细胞具有保护作用，使其免受stx的侵害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effects of Metabolites of Lactobacillus casei on Expression and Neutralization of Shiga Toxin by Enterohemorrhagic Escherichia coli.

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Effects of Metabolites of Lactobacillus casei on Expression and Neutralization of Shiga Toxin by Enterohemorrhagic Escherichia coli.

Shiga toxin (stx), produced by enterohemorrhagic Escherichia coli (EHEC) or Shigella, causes hemolytic uremic syndrome (HUS) in humans. EHEC-mediated illnesses are recommended to treat by immune supportive strategies, instead of antibiotic therapy. Widely used probiotic Lactobacillus casei produces many bioactive metabolites, i.e., conjugated linoleic acids (CLAs) which have potential to educate host immunity and control EHEC growth and expression of its virulence genes. In this study, it was found that total metabolites of L. casei exerted a protective effect on Gb₃ receptor containing mammalian cells against stx exposure.

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.