Lydia Jiang, Jessica Robin, Nathanael Shing, Negar Mazloum-Farzaghi, Natalia Ladyka-Wojcik, Niroja Balakumar, Nicole D. Anderson, Jennifer D. Ryan, Morgan D. Barense, Rosanna K. Olsen
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引用次数: 0
摘要
在阿尔茨海默病(AD)的早期阶段,内侧颞叶(MTL)的颞周皮层(PRC)会出现 Tau 病变,在临床诊断前几十年就会出现。在这里,我们利用针对PRC功能的感知辨别任务来检测即使是名义上健康的老年人的细微认知障碍。我们将没有临床诊断或主观记忆症状的老年人分为 "高危"(得分
Impaired perceptual discrimination of complex objects in older adults at risk for dementia
Tau pathology accumulates in the perirhinal cortex (PRC) of the medial temporal lobe (MTL) during the earliest stages of the Alzheimer's disease (AD), appearing decades before clinical diagnosis. Here, we leveraged perceptual discrimination tasks that target PRC function to detect subtle cognitive impairment even in nominally healthy older adults. Older adults who did not have a clinical diagnosis or subjective memory complaints were categorized into “at-risk” (score <26; n = 15) and “healthy” (score ≥26; n = 23) groups based on their performance on the Montreal Cognitive Assessment. The task included two conditions known to recruit the PRC: faces and complex objects (greebles). A scene condition, known to recruit the hippocampus, and a size control condition that does not rely on the MTL were also included. Individuals in the at-risk group were less accurate than those in the healthy group for discriminating greebles. Performance on either the face or size control condition did not predict group status above and beyond that of the greeble condition. Visual discrimination tasks that are sensitive to PRC function may detect early cognitive decline associated with AD.
期刊介绍:
Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.