比较丘脑-副海马回路中头部方向细胞的发射特征

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Hippocampus Pub Date : 2024-01-04 DOI:10.1002/hipo.23596
Benjamin J. Clark, Patrick A. LaChance, Shawn S. Winter, Max L. Mehlman, Will Butler, Ariyana LaCour, Jeffrey S. Taube
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引用次数: 0

摘要

当动物的头部指向一个特定方向时,头部方向(HD)细胞会持续点燃,人们普遍认为这是动物空间方位感的基础,并已在多个边缘脑区发现了这种细胞。在整个丘脑-副海马系统中都能观察到HD细胞的强烈发射,但最近的研究报告表明,副海马HD细胞表现出与众不同的发射特性,包括与其他空间参数的结合方面,这表明它们在空间处理中扮演着特殊的角色。然而,很少有研究对这些明显的差异进行量化。在这里,我们对背侧丘脑前部(ADN)、丘脑后部(PoS)、丘脑旁部(PaS)、内侧脊髓(MEC)和脊髓后部(POR)皮层的 HD 细胞发射特性进行了比较评估。我们报告说,在所有五个脑区都观察到了具有高度方向特异性的HD细胞,但与海马旁脑区相比,ADN HD细胞在其首选方向上表现出更高的敏锐性和稳定性,以及对未来方向的更高预测性。其他分析表明,与 PoS、PaS 和 MEC 相比,POR HD 细胞受其他空间参数的调节更为粗略。最后,我们的分析表明,在PoS、PaS和MEC中,HD调谐的敏锐度随着层状位置和连接编码的函数而降低,浅层细胞与连接发射特性一起显示出较不稳定的方向调谐。本文结合丘脑-副海马回路中HD细胞调谐的功能组织理论对研究结果进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of head direction cell firing characteristics across thalamo-parahippocampal circuitry

Head direction (HD) cells, which fire persistently when an animal's head is pointed in a particular direction, are widely thought to underlie an animal's sense of spatial orientation and have been identified in several limbic brain regions. Robust HD cell firing is observed throughout the thalamo-parahippocampal system, although recent studies report that parahippocampal HD cells exhibit distinct firing properties, including conjunctive aspects with other spatial parameters, which suggest they play a specialized role in spatial processing. Few studies, however, have quantified these apparent differences. Here, we performed a comparative assessment of HD cell firing characteristics across the anterior dorsal thalamus (ADN), postsubiculum (PoS), parasubiculum (PaS), medial entorhinal (MEC), and postrhinal (POR) cortices. We report that HD cells with a high degree of directional specificity were observed in all five brain regions, but ADN HD cells display greater sharpness and stability in their preferred directions, and greater anticipation of future headings compared to parahippocampal regions. Additional analysis indicated that POR HD cells were more coarsely modulated by other spatial parameters compared to PoS, PaS, and MEC. Finally, our analyses indicated that the sharpness of HD tuning decreased as a function of laminar position and conjunctive coding within the PoS, PaS, and MEC, with cells in the superficial layers along with conjunctive firing properties showing less robust directional tuning. The results are discussed in relation to theories of functional organization of HD cell tuning in thalamo-parahippocampal circuitry.

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来源期刊
Hippocampus
Hippocampus 医学-神经科学
CiteScore
5.80
自引率
5.70%
发文量
79
审稿时长
3-8 weeks
期刊介绍: Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.
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