姜黄素通过 MAPK 信号通路控制七氟醚麻醉后胃癌患者的神经损伤

IF 0.7 4区 材料科学 Q3 Materials Science
Jianguang Ren, Ben Cai
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引用次数: 0

摘要

目前,手术是唯一可以完全切除胃肿瘤的治疗方法。本研究探讨了姜黄素对七氟醚麻醉致胃癌大鼠神经损伤的影响。建立大鼠GC模型,给予七氟醚麻醉。将大鼠分为模型组、低剂量组(20 mg/kg)、高剂量组(60 mg/kg)和空白对照组(每组5只)。为了确定姜黄素与丝裂原活化蛋白激酶(MAPK)表达的相互作用,我们设置MAPK模拟组、MAPK抑制剂组和高剂量姜黄素+MAPK抑制剂组(n = 5),采用Morris水迷宫法检测麻醉后大鼠的认知能力和神经元损伤,同时检测脑源性神经营养因子(BDNF)、神经生长因子(NGF)和焦凋亡的表达。姜黄素可减轻七氟醚诱导的海马神经元损伤和焦亡,促进记忆障碍大鼠的恢复,导致MAPK表达降低,BNDF和NGF表达增加。经MAPK抑制剂治疗后,大鼠海马组织神经损伤得到控制,姜黄素高剂量+MAPK抑制剂组神经保护作用更为显著。因此,姜黄素可以有效上调海马组织中的BNDF和NGF,这与抑制MAPK通路活性密切相关。姜黄素通过抑制焦肽的表达来保护神经系统,有助于改善大鼠的认知障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management of nerve injury by curcumin after sevoflurane anesthesia in gastric cancer through MAPK signaling pathway
Currently, surgery is the only treatment that can completely remove gastric tumor. This study investigated the effect of curcumin on sevoflurane anesthesia-induced nerve damage in rats with gastric cancer (GC). A rat GC model was established and received sevoflurane for anesthesia. The rats were then divided into model group, low-dose (20 mg/kg), high-dose (60 mg/kg) group and blank control group (n = 5, each group). To identify the interaction between curcumin and mitogen-activated protein kinase (MAPK) expression, we set up MAPK mimic group, MAPK inhibitor group, and high-dose curcumin+MAPK inhibitor group (n = 5). The cognitive ability of rats after anesthesia and neuronal damage was assessed using Morris water maze test, whilst the expressions of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and pyroptosis were also detected. Administration of curcumin attenuated neuronal injury and pyroptosis in the hippocampus induced by sevoflurane, and facilitated the recovery of memory impairment in rats, resulting in decreased expression of MAPK and increased expressions of BNDF and NGF. After treatment with MAPK inhibitors, the nerve damage in the rat hippocampus tissue was controlled, and more prominently neuroprotective effect appeared in the curcumin high-dose+MAPK inhibitor group. Curcumin can thus effectively up-regulate BNDF and NGF in hippocampal tissue, which is closely related to inhibited MAPK pathway activity. Curcumin protects the nervous system by inhibiting the expression of pyroptin, contributing toimprovement of cognitive impairment in rats.
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来源期刊
Materials Express
Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
自引率
0.00%
发文量
69
审稿时长
>12 weeks
期刊介绍: Information not localized
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