Victoria Volpari , Meghann Gallouche , Yvan Caspar , Anne Thiebaut-Bertrand , Olivier Épaulard , Patricia Pavese , Caroline Landelle , Marion Le Maréchal
{"title":"非中性粒细胞减少患者的早期picc-line感染主要由大肠杆菌引起，提示第三代头孢菌素可作为一线抗生素治疗。","authors":"Victoria Volpari , Meghann Gallouche , Yvan Caspar , Anne Thiebaut-Bertrand , Olivier Épaulard , Patricia Pavese , Caroline Landelle , Marion Le Maréchal","doi":"10.1016/j.idnow.2023.104842","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To describe the rate of peripherally inserted central catheter (PICC) -associated bloodstream infections, and the pathogens involved.</p></div><div><h3>Methods</h3><p>We prospectively analyzed data collected from all adult patients with a PICC insertion in a hematology unit in a tertiary care center between January 1, 2017 and June 30, 2020.</p></div><div><h3>Results</h3><p>A total of 370 PICCs were inserted in 275 patients with hematological malignancies: 54 (15 %) confirmed cases of central-line associated bloodstream infection (CLABSI) were identified. Enterobacteria were the most frequent bacteria identified, involved in 35 % of CLABSIs. Group 1 enterobacteria bacteremia occurred a much shorter time after insertion (median time to CLABSI 16 days) than group 2 or group 3 enterobacteria (median time to CLABSI 64 days, p-value = 0.049).</p></div><div><h3>Conclusion</h3><p>Among Gram-negative bacilli CLABSI among non-neutropenic patients, <em>E. coli</em> identification was the most frequent and occurred earlier after insertion, suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy for enterobacteria bacteremia among non-neutropenic patients.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 2","pages":"Article 104842"},"PeriodicalIF":2.9000,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266699192300204X/pdfft?md5=b0b0da8c2cae69756573cdb43c363bb3&pid=1-s2.0-S266699192300204X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Early picc-line infections in non-neutropenic patients are mainly due to E. coli suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy\",\"authors\":\"Victoria Volpari , Meghann Gallouche , Yvan Caspar , Anne Thiebaut-Bertrand , Olivier Épaulard , Patricia Pavese , Caroline Landelle , Marion Le Maréchal\",\"doi\":\"10.1016/j.idnow.2023.104842\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>To describe the rate of peripherally inserted central catheter (PICC) -associated bloodstream infections, and the pathogens involved.</p></div><div><h3>Methods</h3><p>We prospectively analyzed data collected from all adult patients with a PICC insertion in a hematology unit in a tertiary care center between January 1, 2017 and June 30, 2020.</p></div><div><h3>Results</h3><p>A total of 370 PICCs were inserted in 275 patients with hematological malignancies: 54 (15 %) confirmed cases of central-line associated bloodstream infection (CLABSI) were identified. Enterobacteria were the most frequent bacteria identified, involved in 35 % of CLABSIs. Group 1 enterobacteria bacteremia occurred a much shorter time after insertion (median time to CLABSI 16 days) than group 2 or group 3 enterobacteria (median time to CLABSI 64 days, p-value = 0.049).</p></div><div><h3>Conclusion</h3><p>Among Gram-negative bacilli CLABSI among non-neutropenic patients, <em>E. coli</em> identification was the most frequent and occurred earlier after insertion, suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy for enterobacteria bacteremia among non-neutropenic patients.</p></div>\",\"PeriodicalId\":13539,\"journal\":{\"name\":\"Infectious diseases now\",\"volume\":\"54 2\",\"pages\":\"Article 104842\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2023-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S266699192300204X/pdfft?md5=b0b0da8c2cae69756573cdb43c363bb3&pid=1-s2.0-S266699192300204X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious diseases now\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S266699192300204X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases now","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266699192300204X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Early picc-line infections in non-neutropenic patients are mainly due to E. coli suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy
Purpose
To describe the rate of peripherally inserted central catheter (PICC) -associated bloodstream infections, and the pathogens involved.
Methods
We prospectively analyzed data collected from all adult patients with a PICC insertion in a hematology unit in a tertiary care center between January 1, 2017 and June 30, 2020.
Results
A total of 370 PICCs were inserted in 275 patients with hematological malignancies: 54 (15 %) confirmed cases of central-line associated bloodstream infection (CLABSI) were identified. Enterobacteria were the most frequent bacteria identified, involved in 35 % of CLABSIs. Group 1 enterobacteria bacteremia occurred a much shorter time after insertion (median time to CLABSI 16 days) than group 2 or group 3 enterobacteria (median time to CLABSI 64 days, p-value = 0.049).
Conclusion
Among Gram-negative bacilli CLABSI among non-neutropenic patients, E. coli identification was the most frequent and occurred earlier after insertion, suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy for enterobacteria bacteremia among non-neutropenic patients.
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