苯妥英在印度尼西亚成人癫痫患者体内的Michaelis-Menten药代动力学分析

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2023-10-10 DOI:10.46542/pe.2023.234.311315

None Sumarno, None Kurnia Kusumastuti, None Junaidi Khotib

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引用次数: 0

摘要

背景:苯妥英的代谢在不同的种族群体中存在差异。因此，作者研究了苯妥英在印度尼西亚成年癫痫患者中的药代动力学。目的:测定并分析苯妥英在成人癫痫患者体内的Michaelis Menten最大流速(Vmax)和Michaelis常数(Km)药动学参数。方法:选择12例成人癫痫患者，根据他们在两种不同的日剂量下有两个可靠的稳态苯妥英血清水平，并且他们需要单独调整苯妥英剂量。结果:成人癫痫患者Vmax值在3.78 ~ 9.65 mg/kg/d之间，Km值在0.71 ~ 5.58 mg/L之间，与年龄、体重无关(p >0.05)。Vmax和Km值表现出个体差异。结论:成人癫痫患者需根据临床反应，根据Vmax和Km参数对苯妥英剂量进行个体化调整，以达到理想的稳态水平。

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An analysis of the Michaelis-Menten pharmacokinetics of phenytoin in epileptic Indonesian adults

Background: Phenytoin metabolism has been shown to vary in different ethnic groups. Therefore, the authors studied phenytoin pharmacokinetics in Indonesian adult patients with epilepsy. Objective: The purpose of this study was to determine and analyse the pharmacokinetic parameters of Michaelis Menten Vmax (maximum velocity) and Km (the Michaelis constant) of phenytoin in adult epileptic patients. Method: Twelve adult epileptic patients were chosen on the basis that they had two reliable steady-state phenytoin serum levels at two different daily doses and they required an additional adjustment of phenytoin dosage monotherapy. Result: The Vmax and Km values for adult epileptic patients respectively, ranged from 3.78 to 9.65 mg/kg/day and from 0.71 to 5.58 mg/L and there was no correlation with age and weight (p > 0.05). The Vmax and Km values have shown individual variability. Conclusion: The optimal adjustment of phenytoin dose individually in adult epileptic patients based on Vmax and Km parameters needs to be done to get the desired steady-state level according to the clinical response.

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.