一种新型的富含没食子丹宁的五倍子提取物(GRE)对健康志愿者重要认知功能的临床评价:一项随机、双盲、安慰剂对照研究

IF 1.3 Q4 FOOD SCIENCE & TECHNOLOGY
Marvin Heuer, Christopher Baker, Michael Sedlak, Kim Jin Woo, Kim Hyun Kee, Debasis Bagchi
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引用次数: 0

摘要

背景:氧化损伤已成为神经退行性疾病发病的重要因素之一,主要是由于a)脑细胞对氧气的使用增加,b)神经元膜中脂质含量增加。这些因素共同导致了脑细胞对ros诱导的脂质过氧化的敏感性升高,对其他细胞大分子(包括核酸和蛋白质)的损伤,以及神经元凋亡、铁凋亡和坏死的死亡。由于损伤部位自由基的持续产生,预防氧化损伤引起的脑卒中或其他不可逆损伤的治疗设计仍然是一个挑战。在这方面,植物来源的单宁和单宁酸衍生物在清除自由基和抑制脂质过氧化方面显示出很好的结果。目的:本研究通过对80名健康成年志愿者连续6周的双盲、安慰剂对照、随机、平行组设计研究,报道了一种富含没食子酸甲酯的苦豆提取物(GRE)对认知功能和整体幸福感的影响。苦豆提取物是苦豆科漆树Rhus javanica L. (Anacardiaceae)上形成的苦豆提取物。结果:早餐后以750毫克/天的剂量服用GRE(与等量的玉米淀粉作为安慰剂),通过HappyNeuroPro(数字治疗工具)和认知工具(迷你精神状态检查(MMSE),蒙特利尔认知评估(MOCA)和成人ADHD自我报告量表(ASRSv1.1)评估,认知功能显着改善。与此同时,经gre治疗的受试者在身体和情绪问题、能量/疲劳、情绪健康和疼痛方面的得分也显著较高(p = 0.033),这是通过估计边际均值的线性独立两两比较评估的,使用alpha = 0.05计算。在全球评估问卷中,超过77%的受试者认为该产品增加了他们的注意力持续时间,并帮助他们提高了70%的记忆力,他们也表示愿意购买市售的GRE。与安慰剂组(13.27 mg/dL)相比,接受gre治疗的受试者的完全代谢谱评估显著降低了血尿素氮(BUN) (11.98 mg/dL) (p = 0.011), SGPT/ALT从28.09 U/L(安慰剂组)降至18.17 U/L (gre组)(p<0.001)。然而,包括心率和收缩压/舒张压在内的重要参数不受GRE提取物消耗的影响。结论:研究表明,GRE可作为一种有效的新型植物疗法,逆转氧化损伤诱导的神经元变性,改善研究个体的认知健康。关键词:五倍子提取物;水芹科;认知功能;多动症;执行功能;口头记忆;安全性、活性氧(ROS)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical evaluation of a novel gallotannin-enriched Galla Rhois extract (GRE) on vital cognitive functions in healthy volunteers: A randomized, double-blind, placebo-controlled study
Background: Oxidative damage has emerged as one of the significant factors in the onset of neurodegenerative disorders, primarily owing to a) higher usage of oxygen by brain cells and b) higher amounts of lipids in the neuronal membranes. Together, these have resulted in higher susceptibility of brain cells to ROS-induced lipid peroxidation, damage to other cellular macromolecules, including nucleic acids and proteins, and death of neurons by apoptosis, ferroptosis, and necrosis. The design of therapeutics to prevent oxidative damage-induced brain stroke or other irreversible injuries has remained a challenge owing to the continuous production of free radicals at the site of damage. In this respect, plant-derived tannins and tannic acid derivatives have exhibited promising results in scavenging free radicals and inhibiting lipid peroxidation.Objective: This investigation reports the effect of Ghala Rois extract (GRE), a methyl gallate enriched gall formed on the nutgall sumac tree, Rhus javanica L. (Anacardiaceae), on enhancing the cognitive function and overall well-being through a double-blind, placebo-controlled, randomized, parallel-group design study on 80 healthy adult volunteers over a period of six consecutive weeks.Results: Administration of GRE in the dosage of 750 mg/day p.o. (with an equal amount of corn starch as a placebo) after breakfast resulted in significant improvement in cognitive functions as assessed by HappyNeuroPro, a digital therapy tool, and the cognitive tools under Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MOCA) and Adult ADHD Self-Reported Scale (ASRSv1.1). Concomitantly, the GRE-treated subjects also scored significantly higher (p = 0.033) in the roles of Physical and Emotional Problems, Energy/Fatigue, Emotional well-being, and pain as evaluated by linearly independent pairwise comparisons among the estimated marginal means and computed using alpha = 0.05. In the Global Evaluation Questionnaire, over 77% of the treated subjects believed that the product increased their attention span, and helped their memory by 70%, and they also indicated their willingness to buy the commercially available GRE. Evaluation of the complete metabolic profile in the GRE-treated subjects significantly lowered the blood urea nitrogen (BUN) (11.98 mg/dL) as compared to placebo (13.27 mg/dL) (p = 0.011) as well as SGPT/ALT from 28.09 U/L (placebo) to 18.17 U/L (GRE-treated) (p<0.001). However, the vital parameters, including heart rate and systolic/diastolic pressure, were not affected by the consumption of GRE extract.Conclusion: The study demonstrated that GRE could be used as an effective new phytotherapeutic for reversing oxidative damage-induced neuronal degeneration and improving cognitive health in these study individuals.Keywords: Galla Rhois extract (GRE); Rhus javanica L. (family Anacardiaceae); Cognitive functions; ADHD; Executive function; Verbal memory; Safety, Reactive Oxygen Species (ROS)
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来源期刊
Functional Foods in Health and Disease
Functional Foods in Health and Disease FOOD SCIENCE & TECHNOLOGY-
CiteScore
2.20
自引率
20.00%
发文量
47
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