光热响应型甲基香豆素三肽螺吡喃的合成及其凝胶化特性

IF 0.7 4区材料科学 Q3 Materials Science

Materials Express Pub Date : 2023-10-01 DOI:10.1166/mex.2023.2522

Guang Tian, Chuanguang Qin

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引用次数: 0

摘要

本研究合成了甲基香豆素-三肽螺吡喃(MC-TPSP)的水凝胶，该凝胶在肽的c端有构象转变。由于螺吡喃型和merocyanine型MC-TPSP和MC-TPMC的异构化，该LMWG可以在凝胶和溶液之间转移。用紫外光谱研究了异构化过程，用扫描电镜表征了MC-TPMC的形貌。转变温度为75℃，最小凝胶浓度为14.5 mM。由于其结构生物相容性和响应性调控机制，预计其将发展成为一种出色的生物功能材料。

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Synthesis and gelation character of photothermal responsive methylcoumarinotripeptidospiropyran

Hydrogel of methylcoumarino-tripeptidospiropyran (MC-TPSP) with a conformational transition at the C-terminus of the peptide was synthesised in this study. This LMWG can be shifted between gel and solution due to the isomerization of spiropyran- and merocyanine-typed MC-TPSP and MC-TPMC, respectively. UV was used to investigate the isomerisation process, and SEM was used to characterise the morphology of the MC-TPMC. The transition temperature was determined to be 75 °C, and the minimum gel concentration was 14.5 mM. On account of its structural biocompatibility and responsive regulatory mechanism, it is anticipated that it will develop into an outstanding bio-functional material.

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来源期刊

Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

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0.00%

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审稿时长

>12 weeks

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