Effects of Grape Juice Consumption in Practitioners of Physical Activity: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

ABSTRACTThe effects of grape juice consumption on oxidative stress, inflammation, physical performance, muscle damage, and recovery in physical activity practitioners were evaluated in clinical studies. However, to date, no studies have gathered these findings. Thus, we aimed to review all randomized clinical trials (RCTs) that evaluated the effects of grape juice consumption on these markers. The searched databases were MEDLINE/PubMed, Embase®, and Cochrane Central, considering an exhaustive search in the literature with keywords uva OR vitis. The PRISMA guideline was used to conduct and report the review. Seven RCTs with athletes (n = 3), recreational sportspeople (n = 3), and low-intensity physical activity practitioners (n = 1) were included. The qualitative results of the individual studies were controversial, and according to the meta-analysis, acute or chronic consumption of 10/ml/kg/day or 400 ml of grape juice improved antioxidant status but had no effects on markers of oxidative stress, inflammation, physical performance, muscle damage and recovery in physical activity practitioners.KEYWORDS: Antioxidantsexhaustion timeathletesrunners Disclosure statementNo potential conflict of interest was reported by the author(s).Availability of data and materialsData are available upon request.Authors contributionsDBB and LMV designed the study. DBB, LMV, and AS selected and reviewed the articles, extracted the data and assessed the risk of bias. DBB, LMV, AS, DJRG, CWS, FARB, and JB analyzed and interpreted the data, wrote the manuscript and approved the final version.Additional informationFundingThis study was funded by Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), by the Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), and by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Finance Code 001).