白花蓼提取物与维生素A、维生素C和硒的组合,作为抗复发性感染的免疫佐剂

IF 1.7 3区 农林科学 Q3 CHEMISTRY, APPLIED
Alejandra Visedo Colino, Flavia Tamara Hernández Rocamora, José Pardo Zapata, Julio Gosálbez, María del Mar Ortega-Villaizán Romo, Regla Maria Medina-Gali, David González Fernández, Alejandro Pérez-Fernández
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引用次数: 0

摘要

植物化学多样性是疾病预防的有效工具,也是常规治疗辅助治疗的基础。在这方面,白芍根茎提取物,PLE,已显示出抗炎症和复发性感染的作用,但其分子机制尚不清楚。这项工作表明,含有PLE、维生素A、C和硒的Plesinox 3A,通过上调IL8和IL10,同时下调COX2、IL1B和TNF,以比单独使用PLE更有效的方式帮助调节细菌LPS引发的初始炎症反应。此外,该制剂通过上调不同细胞类型中的MX1、IFNA1和IFNG来增强抗病毒应答。最后,Plesinox 3A在PLE中添加了维生素和硒,极大地提高了PLE单独的抗菌性能。总的来说,这些发现支持PLE、维生素和硒的联合使用,以Plesinox 3A的形式作为免疫增强剂来预防复发性感染,突出了一组可能参与其有益效果的基因,并显示出其直接的抗菌特性,这比单独使用PLE更大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A combination of Polypodium leucotomos extract with vitamin A, vitamin C and selenium as an immune adjuvant against recurrent infections
Plant chemodiversity is a helpful tool for disease prevention and a basis for adjuvant treatments to conventional therapies. In this regard, the extract of Polypodium leucotomos rhizomes, PLE, has shown benefits fighting inflammation and recurrent infections but its molecular mechanism is poorly undersood. This work shows that Plesinox 3A, containing PLE, Vitamins A, C, and selenium, helps modulate the initial inflammatory response triggered by bacterial LPS through the upregulation of IL8 and IL10, together with downregulation of COX2, IL1B and TNF, in a more efficient manner than PLE alone. Additionally, this formulation enhances the antiviral response through the upregulation of MX1, IFNA1 and IFNG in different cell types. Finally, the addition of vitamins and selenium to PLE in Plesinox 3A greatly boosts the anti-bacterial properties of PLE alone. Overall, these findings support the combined use of PLE, vitamins, and selenium, in the form of Plesinox 3A as an immune booster to prevent recurrent infections, highlighting a gene set potentially involved in its beneficial effect, as well as showing its direct anti-bacterial properties, which are greater than those of PLE alone.
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来源期刊
Food and Agricultural Immunology
Food and Agricultural Immunology 农林科学-毒理学
CiteScore
5.30
自引率
6.70%
发文量
52
审稿时长
2 months
期刊介绍: Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.
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