神经囊虫病患者的人口学特征和临床特征:来自中国大理的回顾性研究。

IF 1.3 Q2 MEDICINE, GENERAL & INTERNAL
Han-Xiao Zhu, Yang-Chao Li, Xue-Ping Yang, Yu-Hao Chu, Wang Guo, Ruo-Xia Chen, Dan-Dan Guo, Li-Jing Cheng, Yun Li
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引用次数: 0

摘要

背景:神经囊虫病(NCC)是一种影响中枢神经系统的主要寄生虫病,具有多种临床表现,是世界范围内获得性癫痫的主要原因,特别是在中国等低收入、中等收入和中高收入国家。在中国,云南省承担着这一疾病的重大负担。目的:了解云南省大理市NCC患者的人口统计学、临床、影像学特征以及血清和脑脊液中囊尾蚴抗体的检测情况。材料和方法:本回顾性研究纳入了2018年1月至2023年5月在大理大学第一附属医院诊断为NCC的患者,这些患者居住在中国云南省大理市。结果:共纳入NCC患者552例,其中白族占33.3%。NCC的临床表现受到寄生虫数量、位置和分期等因素的影响。癫痫/发作(49.9%)是最常见的症状,在囊肿退行性阶段发生率较高(P < 0.001)。与其他部位相比,位于脑实质的囊虫更容易导致癫痫发作/癫痫(OR = 17.45, 95% CI: 7.96 ~ 38.25)和头痛(OR = 3.02, 95% CI: 1.23 ~ 7.41)。与钙化期相比,囊性囊肿(OR = 2.71, 95% CI: 1.12-6.61)和退行性囊肿(OR = 102.38, 95% CI: 28.36-369.60)期患者更容易发作/癫痫。癫痫发作不依赖于病变的数量。所有NCC患者都接受了驱虫药治疗,其中大多数患者接受阿苯达唑治疗(79.7%)。结论:本研究为大理NCC患者提供了有价值的临床见解,并强调了NCC作为癫痫主要可预防原因的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Demographics and Clinical Characteristics of Patients with Neurocysticercosis: A Retrospective Study from Dali, China.

Background: Neurocysticercosis (NCC), a predominant parasitic disease that affects the central nervous system and presents with diverse clinical manifestations, is a major contributor to acquired epilepsy worldwide, particularly in low-, middle-, and upper middle-income nations, such as China. In China, the Yunnan Province bears a significant burden of this disease.

Objective: To describe the demographic, clinical, and radiological features as well as serum and cerebrospinal fluid antibodies to cysticercus in patients with NCC from Dali, Yunnan Province, China.

Materials and methods: This retrospective study included patients who were diagnosed with NCC at The First Affiliated Hospital of Dali University between January 2018 and May 2023 and were residing in Dali, Yunnan Province, China.

Results: A total of 552 patients with NCC were included, of which 33.3% belonged to Bai ethnicity. The clinical presentation of NCC exhibited variability that was influenced by factors such as the number, location, and stage of the parasites. Epilepsy/seizure (49.9%) was the most prevalent symptom, with higher occurrence in the degenerative stage of cysts (P < 0.001). Compared with other locations, cysticerci located in the brain parenchyma are more likely to lead to seizures/epilepsy (OR = 17.45, 95% CI: 7.96-38.25) and headaches (OR = 3.02, 95% CI: 1.23-7.41). Seizures/epilepsy are more likely in patients with cysts in the vesicular (OR = 2.71, 95% CI: 1.12-6.61) and degenerative (OR = 102.38, 95% CI: 28.36-369.60) stages than those in the calcified stage. Seizures was not dependent on the number of lesions. All NCC patients underwent anthelminthic therapy, with the majority receiving albendazole (79.7%).

Conclusion: This study provides valuable clinical insights into NCC patients in Dali and underscores the significance of NCC as a leading preventable cause of epilepsy.

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来源期刊
Saudi Journal of Medicine & Medical Sciences
Saudi Journal of Medicine & Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
52
审稿时长
15 weeks
期刊介绍: Saudi Journal of Medicine & Medical Sciences (SJMMS) is the official scientific journal of Imam Abdulrahman Bin Faisal University. It is an international peer-reviewed, general medical journal. The scope of the Journal is to publish research that will be of interest to health specialties both in academic and clinical practice. The Journal aims at disseminating high-powered research results with the objective of turning research into knowledge. It seeks to promote scholarly publishing in medicine and medical sciences. The Journal is published in print and online. The target readers of the Journal include all medical and health professionals in the health cluster such as in medicine, dentistry, nursing, applied medical sciences, clinical pharmacology, public health, etc.
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