Modeling and simulation of the first phase of the viscoelastic biological particles considering simultaneous roughness of tip, particle, and substrate

In recent years, atomic force microscopy as a basic tool for nanoparticles displacement and manufacturing of intended subjects from atoms and molecules has attracted researchers in different fields such as drug delivery, tissue engineering and etc. Manipulation simulation of the AFM nanorobot is a fundamental tool for controlled and accurate displacement of subjects and particles in different scales. Since passing from macro to micro and nanoscales causes the increased ratio of the area to volume consequently surface forces such as friction and adhesion become more important. According to the surface roughness in contact, critical time and force have been extracted in this paper considering particle and substrate roughness simultaneously to find out the effect of the surface roughness on critical parameters. Therefore, developed rough models for viscoelastic state have been used and asperities radius using experimental test on cancer cells has been extracted to increase simulation accuracy. Results show that the critical force for the elastic, rough viscoelastic and viscoelastic models have higher magnitudes respectively. This difference between elastic and viscoelastic models are completely obvious but between two viscoelastic models are less.