将传热阻力测量集成到数字微流控平台上，以实现生物分子相互作用的小型化和自动化无标记检测

2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS) Pub Date : 2014-03-13 DOI:10.1109/MEMSYS.2014.6765628

E. Pérez-Ruiz, T. Vandenryt, D. Witters, D. Decrop, B. van Grinsven, D. Spasic, P. Wagner, J. Lammertyn

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引用次数: 0

摘要

本文成功地将传热阻测量与数字微流控芯片集成在一起。集成的小型化平台允许生物分子相互作用的自动无标签检测。为了将生物分子固定在疏水芯片表面，亲水金传感贴片是通过最近描述的一种不影响芯片表面的干燥升空技术创建的。进行DNA熔化分析以验证集成装置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Integration of heat-transfer resistance measurements onto a digital microfluidic platform towards the miniaturized and automated label-free detection of biomolecular interactions

In this paper the successful integration of heat-transfer resistance measurements with a digital microfluidic chip is shown. The integrated miniaturized platform allows the automated label-free detection of biomolecular interactions. To immobilize biomolecules on the hydrophobic chip surface, hydrophilic gold sensing patches are created by means of a recently described dry lift-off technique that leaves the chip surface unaffected. DNA melting analysis was performed for validating the integrated device.

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来源期刊

2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS)

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