模拟组织微流体装置对单细胞的局部刺激

TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference Pub Date : 2009-06-21 DOI:10.1109/SENSOR.2009.5285887

K. Terao, A. Okonogi, T. Okitsu, T. Suzuki, M. Washizu, H. Kotera

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引用次数: 0

摘要

在本文中，我们开发了一种新的装置，用于分析细胞内对外界刺激的反应，在单细胞水平上具有高空间分辨率，模拟体内组织微环境。我们利用多向紫外光刻技术实现了组织模拟装置的简单三维制造。制备了侧壁带孔的微通道。局部传递刺激到单个细胞在这里被证明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Local stimulation to single cell on tissue-mimicking microfluidic device

In this paper, we developed a novel device for the analysis of intracellular response to external stimulus in single-cell level with high-spatial resolution that simulates in vivo tissue micro-environment. We utilized multidirectional UV lithography technique to realize simple 3-dimentional fabrication of the tissue-mimicking device. Microchannel with an aperture at its sidewall was fabricated. Localized delivery of stimuli to single cell was demonstrated here.

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TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference

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