Jennie H. Appel, Mandy L. Y. Sin, J. Liao, J. Chae
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Wrinkle cellomics: Screening bladder cancer cells using an ultra-thin silicone membrane
We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns - number, length, and direction of wrinkles - can be visualized by a conventional microscopy. Quantitative measurement of these wrinkling patterns represent a powerful, non-invasive diagnostic tool for prevalent cancers, such as bladder cancer.
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