用脉搏波速度评价高血压和糖尿病患者的动脉僵硬度

Hongyu Wang, Jiyun Wang, Jinbo Liu, Yingyan Zhou, Huan Liu
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摘要

Â背景:动脉硬化是血管疾病的独立预测因子。颈-股脉波速度(CFPWV)是动脉僵硬度的可靠指标。在本研究中,我们探讨了高血压和糖尿病(DM)受试者中可能涉及CFPWV的危险因素。方法:首钢体检中心的425例受试者(男/女168/257)分为健康组(185)、高血压组(135)、糖尿病组(32)、高血压合并糖尿病组(73)。CFPWV用Complior仪测量。结果:高血压合并糖尿病组CFPWV显著高于健康组和高血压组(12.00+2.57 vs 10.12+2.28 m/s;12.00+2.57 vs 10.78+2.07 m/s, p均<0.05)。CFPWV与全组年龄、收缩压(SBP)、舒张压(DBP)、脉压(PP)、空腹血糖(FBG)、HbA1c、尿酸、Log NT-proBNP、Log尿白蛋白(微量白蛋白)排泄[Log UAE]呈正相关(r=0.437、0.410、0.206、0.423、0.210、0.275、0.130、0.135、0.166,p均<0.05)。多因素分析显示,年龄、体重指数、收缩压、PP、FBG是所有受试者CFPWV的独立相关因素(I²=0.287,p<0.001;I²= -0.194,p=0.003;我²= 0.223,p = 0.001;我²= 0.293,p < 0.001;我²= 0.161,p = 0.008;分别)。结论:我们目前的研究表明,与健康组和高血压组相比,高血压合并糖尿病患者的CFPWV明显更高。关键词:颈-股脉波速度;高血压;糖尿病
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Arterial stiffness evaluation by pulse wave velocity in hypertension and diabetes mellitus subjects
 Background: Arterial stiffness is an independent predictor for vascular diseases. Carotid-femoral pulse wave velocity (CFPWV) is a reliable index of arterial stiffness. In the present study, we investigated the possible risk factors involving CFPWV in hypertension and diabetes mellitus (DM) subjects.Methods: 425 subjects (M/F 168/257) from Shougang Corporation Examination Center were divided into four groups: healthy group (n=185), hypertension group (n=135), DM group (n=32), hypertension with DM group (n=73). CFPWV was measured by Complior apparatus.Results: Our results showed that CFPWV was significantly higher in hypertension subjects with DM than in healthy and hypertension group, respectively (12.00+2.57 vs 10.12+2.28 m/s; 12.00+2.57 vs 10.78+2.07 m/s, both p<0.05). CFPWV was positively correlated with age, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), fasting plasma glucose ( FBG), HbA1c, uric acid, Log NT-proBNP and Log Urine Albumin (microalbumin) Excretion [Log UAE] in the entire group(r=0.437, 0.410, 0.206, 0.423, 0.210, 0.275, 0.130, 0.135, 0.166, all p<0.05, respectively). Multivariate analysis showed that age, body mass index, SBP, PP, FBG were independent associating factors of CFPWV in all subjects (I²=0.287, p<0.001; I²= -0.194, p=0.003; I²=0.223, p=0.001; I²=0.293, p<0.001; I²=0.161, p=0.008; respectively).Conclusions: Our present study suggested that CFPWV was significantly higher in hypertension subjects with DM compared to healthy and hypertension groups.Keywords: Carotid-femoral pulse wave velocity; Hypertension; Diabetes mellitus
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