沉香精油吸入通过调节Glu/GABA系统稳态发挥抗焦虑和抗抑郁作用。

IF 2.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Canhong Wang, Bao Gong, Yangyang Liu, Deli Chen, Yulan Wu, Jianhe Wei
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引用次数: 0

摘要

抑郁和焦虑是危害个体身心健康的常见病。沉香吸入作为放松和改善睡眠的传统中药已有几个世纪的历史。沉香精油注射液具有抗焦虑和抗抑郁的作用。因此,本研究进一步研究了吸入AEO对间氯苯哌嗪致焦虑小鼠和慢性不可预测轻度应激致抑郁小鼠的抗焦虑和抗抑郁作用。结果表明,AEO具有明显的抗焦虑作用,在明暗探索试验和开阔场地试验中抑制自主运动。此外,尾悬试验和强迫游泳试验表明,AEO也有抗抑郁作用,从而减少静止时间。此外,AEO还能提高焦虑小鼠5-羟色胺、γ-氨基丁酸(GABA) A受体(GABAA)和谷氨酸(Glu)水平,抑制抑郁小鼠GABAA和Glu水平。进一步研究AEO对Glu/GABA系统的影响表明,AEO显著提高了GABA转氨酶(GABAT)、谷氨酸代谢受体5 (GRM5)、谷氨酸嗜离子受体AMPA型亚基1 (GluR1)和谷氨酸囊泡转运蛋白1 (VGluT1)的蛋白表达水平。此外,AEO降低了GABAT、谷氨酸嗜离子受体NMDA型亚基2B和GRM5的表达水平,提高了GluR1和VGluT1的表达水平。这些结果表明,AEO可能具有抗焦虑和抗抑郁的特性。本研究确定其机制与调节Glu/GABA神经递质系统稳态有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Agarwood essential oil inhalation exerts antianxiety and antidepressant effects via the regulation of Glu/GABA system homeostasis.

Agarwood essential oil inhalation exerts antianxiety and antidepressant effects via the regulation of Glu/GABA system homeostasis.

Agarwood essential oil inhalation exerts antianxiety and antidepressant effects via the regulation of Glu/GABA system homeostasis.

Agarwood essential oil inhalation exerts antianxiety and antidepressant effects via the regulation of Glu/GABA system homeostasis.

Depression and anxiety are common diseases that endanger the physical and mental health of individuals. Agarwood incense inhalation has been used as a traditional Chinese medicine for relaxation and to improve sleep for centuries. In a previous study by the authors it was demonstrated that agarwood essential oil (AEO) injection exerted anxiolytic and antidepressant effects. Therefore the present study further investigated the anxiolytic and antidepressant effects of AEO inhalation on anxiolytic mice induced by M-chlorophenylpiperazine and depressive mice induced by chronic unpredictable mild stress. The results demonstrated that AEO exerted a significant anxiolytic effect, whereby autonomous movements were inhibited during the light dark exploration test and open field test. Furthermore, the tail suspension test and the forced swimming test demonstrated that AEO also exerted an antidepressant effect, whereby the immobility times were decreased. Moreover, AEO was determined to increase the levels of 5-hydroxytryptamine, γ-aminobutyric acid (GABA) A receptor (GABAA) and glutamate (Glu) in anxiolytic mice and inhibit the levels of GABAA and Glu in depressive mice. Further investigations into how AEO affected the Glu/GABA system demonstrated that AEO markedly increased the protein expression levels of GABA transaminase (GABAT), glutamate metabotropic receptor 5 (GRM5), glutamate ionotropic receptor AMPA type subunit 1 (GluR1) and vesicular glutamate transporter 1 (VGluT1). Furthermore, AEO reduced the expression levels of GABAT, glutamate ionotropic receptor NMDA type subunit 2B and GRM5, and enhanced the expression levels of GluR1 and VGluT1. These results demonstrated that AEO potentially possesses antianxiety and antidepressant properties. The present study determined that the mechanism was related to the regulation of Glu/GABA neurotransmitter system homeostasis.

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来源期刊
Biomedical reports
Biomedical reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.10
自引率
0.00%
发文量
86
期刊介绍: Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.
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