日本早产儿胆红素脑病第二次全国调查

IF 1.4 4区 医学 Q4 CLINICAL NEUROLOGY
Akihisa Okumura , Ichiro Morioka , Hiroshi Arai , Masahiro Hayakawa , Yoshihiro Maruo , Takashi Kusaka , Tetsuya Kunikata , Sota Iwatani
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引用次数: 0

摘要

方法 我们在全国范围内开展了一项回顾性问卷调查。首次调查确定了 2000 年后出生的早产儿胆红素脑病患儿人数。第二次调查采用结构化问卷,明确了 pBE 患儿的临床表现和特征,包括人口统计学数据、神经系统症状、核磁共振成像和听性脑干反应(ABR)结果。在排除了先前研究中的患者后,二次调查收集了 30 名患者(21 名男孩和 9 名女孩)的临床信息。慢性肺部疾病和无症状动脉导管未闭是常见的新生儿并发症。63%的患者可以控制头部,17%的患者可以控制功能性步态。57%的患者能有目的地使用手,50%的患者能进行语言交流。核磁共振成像显示,30名患者中有29人的苍白球出现T2高密度。15名患者中有11名出现ABR异常。在2017年和2021年的调查中,所有变量均无明显差异。结论pBE婴儿的大运动功能严重受损,手功能和语言交流能力相对较好。核磁共振成像和 ABR 结果有助于 pBE 的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Second nationwide survey of bilirubin encephalopathy in preterm infants in Japan

Objectives

To determine the clinical features of bilirubin encephalopathy in preterm infants (pBE) in Japan.

Methods

We performed a retrospective, nationwide questionnaire-based survey. The initial survey determined the number of children with pBE who were born after 2000. Using a structured questionnaire, the second survey clarified the clinical manifestations and characteristics of children with pBE, including demographic data, neurological symptoms, and MRI and auditory brainstem response (ABR) findings.

Results

The initial survey identified 41 pBE infants from 18 institutions. After exclusion of patients included in previous studies, clinical information was collected from 30 patients (21 boys and 9 girls) during the secondary survey. The median gestational age was 26 weeks and the median birthweight was 846 g. Chronic lung disease and symptomatic patent ductus arteriosus were common neonatal complications. Head control was observed in 63% and functional gait in 17% of patients. Purposeful hand use was seen in 57% and verbal communication in 50% of patients. MRI showed T2 hyperintensities in the globus pallidus of 29 of 30 patients. ABR abnormalities were present in 11 of 15 patients. None of the variables were significantly different between the 2017 and 2021 surveys.

Conclusions

The pBE infants had severely impaired gross motor function and relatively preserved manual function and verbal communication. MRI and ABR findings aid in the diagnosis of pBE.

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来源期刊
Brain & Development
Brain & Development 医学-临床神经学
CiteScore
3.60
自引率
0.00%
发文量
153
审稿时长
50 days
期刊介绍: Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.
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