一个经过验证的疼痛基因纲要。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Eric Wistrom, Rebecca Chase, Patrick R Smith, Zachary T Campbell
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引用次数: 3

摘要

新型疼痛疗法的发展取决于对潜在靶点的识别和严格验证。模式生物提供了一种方法来测试特定基因和调节元件在疼痛中的作用。在这里,我们提供了一个与疼痛相关行为相关的基因列表。我们利用跨越三十年的结果来确定一组242个基因。它们支持多种功能,包括动作电位传播、免疫应答、GPCR信号传导、酶催化、核酸调节和细胞间信号传导。利用现有的组织和单细胞高通量RNA测序数据集,我们研究了它们的表达模式。对于每个基因类,我们讨论原型成员,重点是额外实验的机会。最后,我们讨论了如何使用强大且日益普遍的前向遗传筛查方法来提高我们识别疼痛基因的能力。本文分类如下:神经系统疾病>遗传学/基因组学/表观遗传学神经系统疾病>分子和细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A compendium of validated pain genes.

A compendium of validated pain genes.

A compendium of validated pain genes.

A compendium of validated pain genes.

The development of novel pain therapeutics hinges on the identification and rigorous validation of potential targets. Model organisms provide a means to test the involvement of specific genes and regulatory elements in pain. Here we provide a list of genes linked to pain-associated behaviors. We capitalize on results spanning over three decades to identify a set of 242 genes. They support a remarkable diversity of functions spanning action potential propagation, immune response, GPCR signaling, enzymatic catalysis, nucleic acid regulation, and intercellular signaling. Making use of existing tissue and single-cell high-throughput RNA sequencing datasets, we examine their patterns of expression. For each gene class, we discuss archetypal members, with an emphasis on opportunities for additional experimentation. Finally, we discuss how powerful and increasingly ubiquitous forward genetic screening approaches could be used to improve our ability to identify pain genes. This article is categorized under: Neurological Diseases > Genetics/Genomics/Epigenetics Neurological Diseases > Molecular and Cellular Physiology.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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