空间组学的黎明。

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2023-08-04 DOI:10.1126/science.abq4964

Dario Bressan, Giorgia Battistoni, Gregory J. Hannon

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引用次数: 6

摘要

空间组学被广泛认为是生命科学的新前沿。这个术语涵盖了广泛的技术，有望通过同时测量物理组织结构和分子特征来改变生物学的许多领域，并最终彻底改变病理学。尽管该领域在过去5年中成熟，但它仍然面临着一些成长的痛苦：进入壁垒、稳健性、实验设计和分析的最佳实践不明确，以及缺乏标准化。在这篇综述中，我们提出了一个不同家族的空间组学技术的系统目录；强调他们的原则、权力和局限性；并就这一强大但仍难以驾驭的局面中面临的最大挑战提出一些观点和建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The dawn of spatial omics

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The dawn of spatial omics

Spatial omics has been widely heralded as the new frontier in life sciences. This term encompasses a wide range of techniques that promise to transform many areas of biology and eventually revolutionize pathology by measuring physical tissue structure and molecular characteristics at the same time. Although the field came of age in the past 5 years, it still suffers from some growing pains: barriers to entry, robustness, unclear best practices for experimental design and analysis, and lack of standardization. In this Review, we present a systematic catalog of the different families of spatial omics technologies; highlight their principles, power, and limitations; and give some perspective and suggestions on the biggest challenges that lay ahead in this incredibly powerful—but still hard to navigate—landscape.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

期刊介绍： Science is a leading outlet for scientific news, commentary, and cutting-edge research. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. Science’s authorship is global too, and its articles consistently rank among the world's most cited research. Science serves as a forum for discussion of important issues related to the advancement of science by publishing material on which a consensus has been reached as well as including the presentation of minority or conflicting points of view. Accordingly, all articles published in Science—including editorials, news and comment, and book reviews—are signed and reflect the individual views of the authors and not official points of view adopted by AAAS or the institutions with which the authors are affiliated. Science seeks to publish those papers that are most influential in their fields or across fields and that will significantly advance scientific understanding. Selected papers should present novel and broadly important data, syntheses, or concepts. They should merit recognition by the wider scientific community and general public provided by publication in Science, beyond that provided by specialty journals. Science welcomes submissions from all fields of science and from any source. The editors are committed to the prompt evaluation and publication of submitted papers while upholding high standards that support reproducibility of published research. Science is published weekly; selected papers are published online ahead of print.