Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection.

IF 2.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Meiling Yu, Sheng Wu, Benquan Qi, Xiaofei Wu, Ximing Deng
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引用次数: 0

Abstract

Tigecycline, a tetracycline antibiotic, is widely used against antimicrobial resistance; therefore, medical staff should use tigecycline rationally to improve clinical efficacy and reduce resistance to this drug. The present study aimed to enhance the rate of rational tigecycline usage. The patients were divided into a low-dose (50 mg tigecycline twice daily, every 12 h) and a high-dose group (100 mg twice daily, every 12 h). The blood concentrations of tigecycline were examined and the area under the curve (AUC)0-12 h values of the two groups were calculated. Prescriptions of tigecycline for 40 intensive care unit (ICU) cases were reviewed to evaluate the rationality of tigecycline usage. The peak plasma concentrations (the 7th administration after 1 h) of tigecycline were significantly higher in the high-dose group (2.46±0.43 µg/ml) compared with those in the low-dose group (1.25±0.16 µg/ml). The AUC0-12 h was 16.35±3.09 h µg/ml in the high-dose group and 9.83±1.23 h µg/ml in the low-dose group (P<0.001). There were 29 irrational prescriptions identified, involving: i) Lack of consultation records (n=20); ii) inappropriate usage or dosage (n=17); iii) inappropriate drug selection (n=2); or iv) lack of dynamic laboratory tests to evaluate the efficacy (n=4). The irrational use of tigecycline in ICU patients is common. The rate of rational tigecycline usage can be improved by strengthening the management, training and participation of clinical pharmacists.

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重症感染患者合理使用替加环素及监测替加环素血药浓度。
替加环素是一种四环素类抗生素,广泛用于抗微生物药物耐药性;因此,医务人员应合理使用替加环素,提高临床疗效,减少对该药的耐药。本研究旨在提高替加环素的合理使用率。将患者分为低剂量组(50 mg替加环素每日2次,每12 h)和高剂量组(100 mg替加环素每日2次,每12 h),检测两组患者的血药浓度,计算两组患者0-12 h的曲线下面积(AUC)。对40例重症监护病房(ICU)患者的替加环素处方进行回顾性分析,评价其使用的合理性。替加环素高剂量组(1 h后第7次给药)血药浓度峰值(2.46±0.43µg/ml)显著高于低剂量组(1.25±0.16µg/ml)。高剂量组AUC0-12 h为16.35±3.09 hµg/ml,低剂量组AUC0-12 h为9.83±1.23 hµg/ml (P
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来源期刊
Biomedical reports
Biomedical reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.10
自引率
0.00%
发文量
86
期刊介绍: Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.
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